1,3-Propanesultam
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1,3-Propanesultam (1,1-Dioxoisothiazolidine) is a cyclic sulfonamide monomer. Polymerization of 1,3-Propanesultam under base catalysis produces high-molecular-weight polypropanesulfonamide, while polymerization under acid catalysis yields low-molecular-weight polypropanesulfonamide. 1,3-Propanesultam serves as a coupling partner in copper-catalyzed C-N cross-coupling reactions for the synthesis of 3-aminopyrazole phenylacetamide analogs. 1,3-Propanesultam is applicable to research related to organic synthesis.
For research use only. We do not sell to patients.
- Purity: 98.50%
- CAS No.: 5908-62-3
- Formula: C3H7NO2S
- Molecular Weight:121.16
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1,3-Propanesultam can be used to prepare APPA derivative 48 bearing a sultam functional group, which undergoes high-throughput screening for Ube3a unsilencing and cytotoxicity in primary neurons from pINSG mice[1].
1,3-Propanesultam generates high-molecular-weight polypropanesulfonamide via base-catalyzed polymerization, but only low-molecular-weight polypropanesulfonamide can be obtained through acid-catalyzed polymerization[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5908-62-3
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Appearance Solid-Liquid Mixture
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Molecular Weight 121.16
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Formula C3H7NO2S
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Color Colorless to off-white
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SMILES
O=S1(NCCC1)=O
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Synonyms
1,1-Dioxoisothiazolidine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (825.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.2535 mL | 41.2677 mL | 82.5355 mL | 206.3387 mL |
| 5 mM | 1.6507 mL | 8.2535 mL | 16.5071 mL | 41.2677 mL | |
| 10 mM | 0.8254 mL | 4.1268 mL | 8.2535 mL | 20.6339 mL | |
| 15 mM | 0.5502 mL | 2.7512 mL | 5.5024 mL | 13.7559 mL | |
| 20 mM | 0.4127 mL | 2.0634 mL | 4.1268 mL | 10.3169 mL | |
| 25 mM | 0.3301 mL | 1.6507 mL | 3.3014 mL | 8.2535 mL | |
| 30 mM | 0.2751 mL | 1.3756 mL | 2.7512 mL | 6.8780 mL | |
| 40 mM | 0.2063 mL | 1.0317 mL | 2.0634 mL | 5.1585 mL | |
| 50 mM | 0.1651 mL | 0.8254 mL | 1.6507 mL | 4.1268 mL | |
| 60 mM | 0.1376 mL | 0.6878 mL | 1.3756 mL | 3.4390 mL | |
| 80 mM | 0.1032 mL | 0.5158 mL | 1.0317 mL | 2.5792 mL | |
| 100 mM | 0.0825 mL | 0.4127 mL | 0.8254 mL | 2.0634 mL |
1,3-Propanesultam Related Classifications
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