country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N12360

Copy Link Print Information

2,3-Dehydrosilybin A

2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound.

For research use only. We do not sell to patients.

CAS No.: 25166-14-7
Formula: C₂₅H₂₀O₁₀
Molecular Weight:480.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

2,3-Dehydrosilybin A Chemical Structure

CAS No.: 25166-14-7

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.48 μM Compound: 2	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
HUVEC	IC₅₀	12 μM Compound: 1	Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 27015547]
HUVEC	IC₅₀	12.2 μM Compound: 1	Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis	[PMID: 27015547]
HUVEC	IC₅₀	5.4 μM Compound: 1	Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 27015547]
LNCaP	IC₅₀	3.09 μM Compound: 2	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
PC-12	EC₅₀	30.2 μM Compound: DHS	Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay	[PMID: 19673490]
PC-3	IC₅₀	9.45 μM Compound: 2	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
Rat1	IC₅₀	155 μM Compound: DHS, enantiomeric mixture	Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay	[PMID: 21737270]

In Vitro

2,3-dehydrosilybin A (DHS A) promotes lifespan extension in C. elegans^[1].
2,3-dehydrosilybin A promotes resistance to stress in human cells and in C. elegans^[1].
2,3-dehydrosilybin A exerts anti-aggregation properties in human cells and nematodes^[1].
2,3-dehydrosilybin A leads to decelerated progression of Alzheimer's disease phenotype^[1].
2,3-dehydrosilybin A outcomes in C. elegans are FGT-1- and DAF-16- dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 25166-14-7
Molecular Weight 480.42
Formula C₂₅H₂₀O₁₀
SMILES

OC[C@@H]1[C@@H](C2=CC(OC)=C(C=C2)O)OC3=CC(C(OC4=CC(O)=CC(O)=C45)=C(O)C5=O)=CC=C3O1
Structure Classification
- Flavonoids
- Flavonols
Initial Source
- Plants
- Compositae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Konstantina Filippopoulou, et al. 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med. 2017 Feb:103:256-267. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote