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製品番号: HY-N12360

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2,3-Dehydrosilybin A

Name: 2,3-Dehydrosilybin A
Brand: MedChemExpress
SKU: HY-N12360
Price: 389.00 USD
Availability: InStock
Rating: 5 (1 reviews)

2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 25166-14-7
分子式: C₂₅H₂₀O₁₀
分子量:480.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

2,3-Dehydrosilybin A 構造式

CAS 番号: 25166-14-7

容量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.48 μM Compound: 2	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
HUVEC	IC₅₀	12 μM Compound: 1	Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 27015547]
HUVEC	IC₅₀	12.2 μM Compound: 1	Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis	[PMID: 27015547]
HUVEC	IC₅₀	5.4 μM Compound: 1	Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 27015547]
LNCaP	IC₅₀	3.09 μM Compound: 2	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
PC-12	EC₅₀	30.2 μM Compound: DHS	Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay	[PMID: 19673490]
PC-3	IC₅₀	9.45 μM Compound: 2	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
Rat1	IC₅₀	155 μM Compound: DHS, enantiomeric mixture	Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay	[PMID: 21737270]

体外実験

2,3-dehydrosilybin A (DHS A) promotes lifespan extension in C. elegans^[1].
2,3-dehydrosilybin A promotes resistance to stress in human cells and in C. elegans^[1].
2,3-dehydrosilybin A exerts anti-aggregation properties in human cells and nematodes^[1].
2,3-dehydrosilybin A leads to decelerated progression of Alzheimer's disease phenotype^[1].
2,3-dehydrosilybin A outcomes in C. elegans are FGT-1- and DAF-16- dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 25166-14-7
分子量 480.42
分子式 C₂₅H₂₀O₁₀
SMILES

OC[C@@H]1[C@@H](C2=CC(OC)=C(C=C2)O)OC3=CC(C(OC4=CC(O)=CC(O)=C45)=C(O)C5=O)=CC=C3O1
Structure Classification
- Flavonoids
- Flavonols
Initial Source
- Plants
- Compositae
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Konstantina Filippopoulou, et al. 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med. 2017 Feb:103:256-267. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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