2-Methoxyphenyl dihydrouracil

Cat. No.: HY-W249500 Pureza: 95.11%: Ficha de datos
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2-Methoxyphenyl dihydrouracil (Compound 13) is a CRBN ligand, and can be used for synthesis of PROTACs.

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2-Methoxyphenyl dihydrouracil Estructura química

No. CAS : 2377643-33-7

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	Obtener un presupuesto
50 g	Obtener un presupuesto

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Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Ligands for E3 Ligase:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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Descripciòn

2-Methoxyphenyl dihydrouracil (Compound 13) is a CRBN ligand, and can be used for synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

Cereblon

Peso molecular

264.23

Fòrmula

C₁₂H₁₂N₂O₅

No. CAS

2377643-33-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(OC)C(N(C(N2)=O)CCC2=O)=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 33.33 mg/mL (126.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7846 mL	18.9229 mL	37.8458 mL
5 mM	0.7569 mL	3.7846 mL	7.5692 mL
10 mM	0.3785 mL	1.8923 mL	3.7846 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.0%

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Ficha de datos (270 KB) SDS (393 KB)

COA (249 KB) HNMR (112 KB) MS (150 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang K, et al. Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor. Bioorg Med Chem Lett. 2024 Jul 15;107:129780. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7846 mL	18.9229 mL	37.8458 mL	94.6145 mL
	5 mM	0.7569 mL	3.7846 mL	7.5692 mL	18.9229 mL
	10 mM	0.3785 mL	1.8923 mL	3.7846 mL	9.4615 mL
	15 mM	0.2523 mL	1.2615 mL	2.5231 mL	6.3076 mL
	20 mM	0.1892 mL	0.9461 mL	1.8923 mL	4.7307 mL
	25 mM	0.1514 mL	0.7569 mL	1.5138 mL	3.7846 mL
	30 mM	0.1262 mL	0.6308 mL	1.2615 mL	3.1538 mL
	40 mM	0.0946 mL	0.4731 mL	0.9461 mL	2.3654 mL
	50 mM	0.0757 mL	0.3785 mL	0.7569 mL	1.8923 mL
	60 mM	0.0631 mL	0.3154 mL	0.6308 mL	1.5769 mL
	80 mM	0.0473 mL	0.2365 mL	0.4731 mL	1.1827 mL
	100 mM	0.0378 mL	0.1892 mL	0.3785 mL	0.9461 mL