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Cat. No.: HY-P12400

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2W1S peptide

2W1S peptide is an MHC-II-restricted model epitope derived from a modified I-Eα peptide. 2W1S peptide generates 2W1S-specific CD4⁺ T cells in C57BL/6 mice. 2W1S peptide can be assembled into tetramers for the detection of antigen-specific CD4⁺ T cells. 2W1S-PE conjugates constructed with 2W1S peptide can simultaneously activate antigen-specific B cells and CD4⁺ T cells. 2W1S peptide expressed in Strongyloides ratti Hulk worms induces CD4⁺ T cells that exhibit both Th2 and Treg phenotypes and highly express amphiregulin. 2W1S peptide can be used for research related to CD4⁺ T cell responses.

For research use only. We do not sell to patients.

CAS No.: 1398506-19-8
Formula: C₆₆H₉₃N₁₇O₂₁
Molecular Weight:1460.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

2W1S peptide Chemical Structure

CAS No.: 1398506-19-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

Adaptive Immunity

2W1S peptide (100 μg/mL; 72 h) restimulation of ex vivo whole-lung cultures from Hulk-infected mice induces amphiregulin production at a level approximately one-third of that in the anti-CD3 stimulation group^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adaptive ImmunityBacterial InfectionCytokines & ChemokinesParasitic InfectionImmune Tolerance & Immunosuppression

Adaptive Immunity

Bacterial Infection

2W1S peptide is administered intraperitoneally as a 2W1S‑PE conjugate to immunize female C57BL/6 mice with cecal ligation and puncture-induced sepsis in a single dose; sepsis suppresses the proliferation and differentiation of PE-specific B cells while impairing the expansion of 2W1S-specific CD4⁺ T cells and the differentiation of follicular helper T cells^[2].

Bacterial Infection

Adaptive Immunity

Cytokines & Chemokines

2W1S peptide is expressed by recombinant Listeria monocytogenes, and after intravenous infection of C57BL/6 mice, it induces the generation of 2W1S-specific CD4⁺ T cells; upon infection of C57BL/6 mice and Rorc (γt)^+/GFP reporter mice, only a small number of IL-17A⁺/RORγt⁺ 2W1S-specific CD4⁺ T cells are induced^[1].

Parasitic Infection

Adaptive Immunity

Immune Tolerance & Immunosuppression

2W1S peptide intraperitoneal pre-immunization only upregulates pulmonary amphiregulin and amphiregulin-positive CD3⁺ cells; whereas intratracheal administration of this peptide on day 17 of Hulk infection expands CD11a⁺Ki67⁺ and GATA3⁺Ki67⁺ CD4⁺ T cells and further elevates pulmonary amphiregulin levels^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1398506-19-8
Molecular Weight 1460.55
Formula C₆₆H₉₃N₁₇O₂₁
SMILES

O=C(N[C@@H](C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Sequence

Glu-Ala-Trp-Gly-Ala-Leu-Ala-Asn-Trp-Ala-Val-Asp-Ser-Ala
Sequence Shortening

EAWGALANWAVDSA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pepper M, et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nature immunology. 2010 Jan;11(1):83-9.

[2]. Sjaastad FV, et al. Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses. Frontiers in immunology. 2018;9:2532.

[3]. Douglas B, et al. Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations. PLoS Pathogens, 2021, 17(7): e1009709.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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2W1S peptide

Biological Activity

Description

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

2W1S peptide Related Classifications

HY-P12400 Related Classifications

Bioz

Keywords

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