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Cat. No.: HY-W740364

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3'-Deoxy-3'-fluorothymidine-d₃

3'-Deoxy-3'-fluorothymidine-d₃ is the deuterium labeled Alovudine (HY-B1516). Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity.

For research use only. We do not sell to patients.

CAS No.: 1346523-18-9
Formula: C₁₀H₁₀D₃FN₂O₄
Molecular Weight:247.24

Storage:

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

3'-Deoxy-3'-fluorothymidine-d₃ Chemical Structure

CAS No.: 1346523-18-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1346523-18-9
Unlabeled Cas 25526-93-6
Appearance Solid
Molecular Weight 247.24
Formula C₁₀H₁₀D₃FN₂O₄
Color White to off-white
SMILES

O=C1C(C([2H])([2H])[2H])=CN(C(N1)=O)[C@H]2C[C@@H]([C@H](O2)CO)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)