3-Methoxyphenol
Based on 1 Customer Validation
3-Methoxyphenol is an environmental pollutant. 3-Methoxyphenol occurs in the aroma components of dried bonito. 3-Methoxyphenol potentially enhances GABA-evoked responses of α1β1 GABAA receptors by increasing the affinity of GABA binding sites. 3-Methoxyphenol is used as a flavoring substance in food and animal feed. 3-Methoxyphenol prolongs pentobarbital-induced sleeping time and reduces elevated plus maze behavior.
For research use only. We do not sell to patients.
- Purity : 98.25%
- CAS No.: 150-19-6
- Formula: C7H8O2
- Molecular Weight:124.14
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
3-Methoxyphenol (2-7 days) strongly potentiates the response of α1β1 GABAA receptors expressed in Xenopus oocytes, with an estimated maximum potentiation (Vm) of 535% and a dissociation constant (Kp) of 1.04 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
3-Methoxyphenol (100 mg/kg; i.p.) decreases both open-arm entries and open-arm duration in the elevated plus maze, indicating an anxiogenic-like effect in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR (male, 7-10 weeks, 32-40 g)[2]
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Dosage:100 mg/kg
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Administration:i.p.; single injection 30 min before barbiturate
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Result:Prolonged barbiturate-induced sleeping time compared to control.
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Animal Model:ICR (male, 7-10 weeks, 32-40 g)[2]
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Dosage:100 mg/kg
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Administration:i.p.; twice daily; measurements on third day
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Result:Decreased both the number of entries into the open arms and the duration of stay in the open arms in the elevated plus maze.
Chemical Information
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CAS No. 150-19-6
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Appearance Liquid (Density: 1.131 g/cm3)
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Molecular Weight 124.14
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Formula C7H8O2
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Color Light yellow to yellow
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SMILES
OC1=CC=CC(OC)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (805.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (642 KB)
- English - EN (642 KB)
- Français - FR (642 KB)
- Deutsch - DE (642 KB)
- Norwegian - NO (642 KB)
- Español - ES (642 KB)
- Swedish - SV (642 KB)
- Italian - IT (642 KB)
- Korean - KR (642 KB)
- Portuguese - PT (642 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.0554 mL | 40.2771 mL | 80.5542 mL | 201.3855 mL |
| 5 mM | 1.6111 mL | 8.0554 mL | 16.1108 mL | 40.2771 mL | |
| 10 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL | 20.1386 mL | |
| 15 mM | 0.5370 mL | 2.6851 mL | 5.3703 mL | 13.4257 mL | |
| 20 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL | 10.0693 mL | |
| 25 mM | 0.3222 mL | 1.6111 mL | 3.2222 mL | 8.0554 mL | |
| 30 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
| 40 mM | 0.2014 mL | 1.0069 mL | 2.0139 mL | 5.0346 mL | |
| 50 mM | 0.1611 mL | 0.8055 mL | 1.6111 mL | 4.0277 mL | |
| 60 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 80 mM | 0.1007 mL | 0.5035 mL | 1.0069 mL | 2.5173 mL | |
| 100 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0139 mL |
3-Methoxyphenol Related Classifications
HY-Y1840 Related Classifications
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Keywords
- 3-Methoxyphenol
- 150-19-6
- Environmental Pollutants
- Biochemical Assay Reagents
- GABA Receptor
- subchronic oral toxicity study
- GABA-elicited response
- carcinogenic chemical
- electrochemical sensor
- elevated plus maze
- pentobarbital-induced sleeping time
- katsuobushi
- α1β1 GABAA receptors
- environmental pollutant
- Xenopus oocytes
- Inhibitor
- inhibitor
- inhibit