4-Chlorocinnamaldehyde
Based on 1 Customer Validation
4-Chlorocinnamaldehyde (trans-p-Chlorocinnamaldehyde) is an antiviral agent. 4-Chlorocinnamaldehyde inhibits the replication of Coxsackievirus B3 in cardiomyocytes, but shows poor efficacy in animal experiments. 4-Chlorocinnamaldehyde can be used in studies related to viral myocarditis.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 49678-02-6
- Formula: C9H7ClO
- Molecular Weight:166.60
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
4-Chlorocinnamaldehyde (Compound 2) (0.01-1000 μM; 72 h) shows no obvious cytotoxicity in neonatal rat cardiomyocytes, with a CC50 of 6972.47 μM after 72 h of incubation[1].
4-Chlorocinnamaldehyde (0.01-1000 μM; 72 h) weakly inhibits CVB3 replication in neonatal rat cardiomyocytes, with an IC50 of 2109.08 μM and a therapeutic index of 3.31 after 72 h of incubation[1].
4-Chlorocinnamaldehyde (10 μM; 72 h) inhibits the secretion of proinflammatory cytokines TNF-α, IL-1β and IL-6 induced by CVB3 in neonatal rat cardiomyocytes[1].
4-Chlorocinnamaldehyde (10 μM; 12-24 h) inhibits the mRNA and protein expression of proinflammatory cytokines TNF-α, IL-1β and IL-6 in neonatal rat cardiomyocytes induced by CVB3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CVB3-infected neonatal rat cardiomyocytes
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Concentration:10 μM
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Incubation Time:72 h
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Result:Significantly decreased TNF-α, IL-1β, and IL-6 secretion relative to CVB3-infected control cells.
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Cell Line:CVB3-infected neonatal rat cardiomyocytes
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Concentration:10 μM
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Incubation Time:12 h
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Result:Significantly inhibited TNF-α, IL-1β, and IL-6 mRNA expression relative to CVB3-infected control cells.
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Cell Line:CVB3-infected neonatal rat cardiomyocytes
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Concentration:10 μM
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Incubation Time:24 h
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Result:Significantly reduced TNF-α, IL-1β, and IL-6 protein expression relative to CVB3-infected control cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (four-week-old, male, Coxsackievirus B3-induced viral myocarditis model)[1]
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Dosage:20 mg/kg; 40 mg/kg; 60 mg/kg
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Administration:p.o.; daily; 6 days
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Result:Showed no statistically significant differences in pathological scores or viral titers between any dose group and the model control group.
Chemical Information
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CAS No. 49678-02-6
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Appearance Solid
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Molecular Weight 166.60
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Formula C9H7ClO
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Color White to yellow
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SMILES
C(=C/C=O)\C1=CC=C(Cl)C=C1
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Synonyms
trans-p-Chlorocinnamaldehyde
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (600.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0024 mL | 30.0120 mL | 60.0240 mL | 150.0600 mL |
| 5 mM | 1.2005 mL | 6.0024 mL | 12.0048 mL | 30.0120 mL | |
| 10 mM | 0.6002 mL | 3.0012 mL | 6.0024 mL | 15.0060 mL | |
| 15 mM | 0.4002 mL | 2.0008 mL | 4.0016 mL | 10.0040 mL | |
| 20 mM | 0.3001 mL | 1.5006 mL | 3.0012 mL | 7.5030 mL | |
| 25 mM | 0.2401 mL | 1.2005 mL | 2.4010 mL | 6.0024 mL | |
| 30 mM | 0.2001 mL | 1.0004 mL | 2.0008 mL | 5.0020 mL | |
| 40 mM | 0.1501 mL | 0.7503 mL | 1.5006 mL | 3.7515 mL | |
| 50 mM | 0.1200 mL | 0.6002 mL | 1.2005 mL | 3.0012 mL | |
| 60 mM | 0.1000 mL | 0.5002 mL | 1.0004 mL | 2.5010 mL | |
| 80 mM | 0.0750 mL | 0.3752 mL | 0.7503 mL | 1.8758 mL | |
| 100 mM | 0.0600 mL | 0.3001 mL | 0.6002 mL | 1.5006 mL |
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