4-Hydroxymephenytoin-d₃

Name: 4-Hydroxymephenytoin-d 3
Brand: MedChemExpress
SKU: HY-W008772S
Rating: 5.0 (1 reviews)

Cat. No.: HY-W008772S Purity: 98.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Hydroxymephenytoin-d₃ is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate[1][2].

For research use only. We do not sell to patients.

4-Hydroxymephenytoin-d<sub>3</sub> Chemical Structure

4-Hydroxymephenytoin-d₃ Chemical Structure

CAS No. : 1173022-56-4

Size	Price	Stock	Quantity
1 mg	USD 383	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroxymephenytoin-d₃:

4-Hydroxymephenytoin In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4-Hydroxymephenytoin-d₃ is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

237.27

Formula

C₁₂H₁₁D₃N₂O₃

CAS No.

1173022-56-4

Appearance

Solid

Color

White to light yellow

SMILES

CCC1(C2=CC=C(C=C2)O)C(N(C(N1)=O)C([2H])([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (421.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2146 mL	21.0730 mL	42.1461 mL
5 mM	0.8429 mL	4.2146 mL	8.4292 mL
10 mM	0.4215 mL	2.1073 mL	4.2146 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.73%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (251 KB) LCMS (157 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94. [Content Brief]

[3]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2146 mL	21.0730 mL	42.1461 mL	105.3652 mL
	5 mM	0.8429 mL	4.2146 mL	8.4292 mL	21.0730 mL
	10 mM	0.4215 mL	2.1073 mL	4.2146 mL	10.5365 mL
	15 mM	0.2810 mL	1.4049 mL	2.8097 mL	7.0243 mL
	20 mM	0.2107 mL	1.0537 mL	2.1073 mL	5.2683 mL
	25 mM	0.1686 mL	0.8429 mL	1.6858 mL	4.2146 mL
	30 mM	0.1405 mL	0.7024 mL	1.4049 mL	3.5122 mL
	40 mM	0.1054 mL	0.5268 mL	1.0537 mL	2.6341 mL
	50 mM	0.0843 mL	0.4215 mL	0.8429 mL	2.1073 mL
	60 mM	0.0702 mL	0.3512 mL	0.7024 mL	1.7561 mL
	80 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3171 mL
	100 mM	0.0421 mL	0.2107 mL	0.4215 mL	1.0537 mL