4-Hydroxymephenytoin-d3
Based on 1 Customer Validation
4-Hydroxymephenytoin-d3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate.
For research use only. We do not sell to patients.
- Purity: 99.05%
- CAS No.: 1173022-56-4
- Formula: C12H11D3N2O3
- Molecular Weight:237.27
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1173022-56-4
-
Unlabeled Cas 61837-65-8
-
Appearance Solid
-
Molecular Weight 237.27
-
Formula C12H11D3N2O3
-
Color White to light yellow
-
SMILES
CCC1(C2=CC=C(C=C2)O)C(N(C(N1)=O)C([2H])([2H])[2H])=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (421.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94. [Content Brief]
[3]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2146 mL | 21.0728 mL | 42.1455 mL | 105.3639 mL |
| 5 mM | 0.8429 mL | 4.2146 mL | 8.4291 mL | 21.0728 mL | |
| 10 mM | 0.4215 mL | 2.1073 mL | 4.2146 mL | 10.5364 mL | |
| 15 mM | 0.2810 mL | 1.4049 mL | 2.8097 mL | 7.0243 mL | |
| 20 mM | 0.2107 mL | 1.0536 mL | 2.1073 mL | 5.2682 mL | |
| 25 mM | 0.1686 mL | 0.8429 mL | 1.6858 mL | 4.2146 mL | |
| 30 mM | 0.1405 mL | 0.7024 mL | 1.4049 mL | 3.5121 mL | |
| 40 mM | 0.1054 mL | 0.5268 mL | 1.0536 mL | 2.6341 mL | |
| 50 mM | 0.0843 mL | 0.4215 mL | 0.8429 mL | 2.1073 mL | |
| 60 mM | 0.0702 mL | 0.3512 mL | 0.7024 mL | 1.7561 mL | |
| 80 mM | 0.0527 mL | 0.2634 mL | 0.5268 mL | 1.3170 mL | |
| 100 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0536 mL |
4-Hydroxymephenytoin-d3 Related Classifications
HY-W008772S Related Classifications
Powered by Bioz