2. Membrane Transporter/Ion Channel
  3. CRAC Channel
  4. 5J-4

5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.

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5J-4 Chemical Structure

5J-4 Chemical Structure

CAS No. : 827001-82-1

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Description

5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].

In Vivo

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (MOG35-55 peptide-immunized mice)[1]
Dosage: 2 m/kg
Administration: I.p., every alternate day for 30 days
Result: Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
Molecular Weight

312.34

Formula

C16H12N2O3S
CAS No.
Appearance

Powder

Color

White to off-white

SMILES

O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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5J-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5J-4827001-82-1CRAC ChannelCalcium release-activated channelsCa2+ release-activated Ca2+ channelsCNSexperimental autoimmune encephalomyelitismononuclear cellCD4+ cellsinflammationInhibitorinhibitorinhibit

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