7-Oxodehydroabietic acid
Based on 1 Customer Validation
7-Oxodehydroabietic acid is a diterpene resin acid isolated from the roots of the pine Pinus densiflora. 7-Oxodehydroabietic acid play a defensive role against herbivorous insects via insect endocrine-disrupting activity.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 18684-55-4
- Formula: C20H26O3
- Molecular Weight:314.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 23
|
Cytotoxicity in human A549 cells by SRB assay
Cytotoxicity in human A549 cells by SRB assay
|
[PMID: 26812172] |
| HCT-116 | IC50 |
>10 μM
Compound: 23
|
Cytotoxicity in human HCT116 cells by SRB assay
Cytotoxicity in human HCT116 cells by SRB assay
|
[PMID: 26812172] |
| HEK293 | IC50 |
>100 μg/mL
Compound: 46
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Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells
Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells
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[PMID: 20022253] |
| LoVo | IC50 |
>25 μg/mL
Compound: 46
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Antiproliferative activity against human LoVo cells
Antiproliferative activity against human LoVo cells
|
[PMID: 20022253] |
| QGY-7703 | IC50 |
10.2 μg/mL
Compound: 46
|
Antiproliferative activity against human QGY7703 cells
Antiproliferative activity against human QGY7703 cells
|
[PMID: 20022253] |
| RAW264.7 | IC50 |
>100 μg/mL
Compound: 46
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
|
[PMID: 20022253] |
| SK-MEL-2 | IC50 |
>10 μM
Compound: 23
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Cytotoxicity in human SK-MEL-2 cells by SRB assay
Cytotoxicity in human SK-MEL-2 cells by SRB assay
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[PMID: 26812172] |
| SK-OV-3 | IC50 |
>10 μM
Compound: 23
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Cytotoxicity in human SKOV3 cells by SRB assay
Cytotoxicity in human SKOV3 cells by SRB assay
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[PMID: 26812172] |
7-Oxodehydroabietic acid significantly affects the growth of P. interpunctella larvae[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18684-55-4
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Appearance Solid
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Molecular Weight 314.42
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Formula C20H26O3
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Color White to off-white
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SMILES
O=C([C@]1(C)CCC[C@]2(C)C3=C(C(C[C@@]12[H])=O)C=C(C(C)C)C=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Hyun-Woo Oh, et al. Conifer Diterpene Resin Acids Disrupt Juvenile Hormone-Mediated Endocrine Regulation in the Indian Meal Moth Plodia interpunctella. J Chem Ecol. 2017 Jul;43(7):703-711. [Content Brief]
[2]. Hisashi Kato-Noguchi, et al. Involvement of allelopathy in inhibition of understory growth in red pine forests. J Plant Physiol. 2017 Nov;218:66-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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