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Cat. No.: HY-13678B

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8-epi-Meropenem

Name: 8-epi-Meropenem
Brand: MedChemExpress
SKU: HY-13678B
Availability: PreOrder

(Synonyms: JDB-1-200)

8-epi-Meropenem (JDB-1-200) is a Meropenem (HY-13678) derivative with antibacterial activity. 8-epi-Meropenem is an inhibitor of KPC-2 (IC₅₀ 210 nM) and CTX-M-15 (IC₅₀ 215 nM). 8-epi-Meropenem also acts on bacterial PBPs to interfere with peptidoglycan synthesis. 8-epi-Meropenem has in vitro activity against KPC-producing Enterobacterales, exhibits strain-dependent activity against Acinetobacter baumannii, and has reduced activity against Pseudomonas aeruginosa. 8-epi-Meropenem can be used for research related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 3063333-21-8
Formula: C₁₇H₂₅N₃O₅S
Molecular Weight:383.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

8-epi-Meropenem Chemical Structure

CAS No.: 3063333-21-8

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Biological Activity

Description

All Beta-lactamase Isoforms :

In Vitro

OthersBacterial Infection

Others

8-epi-Meropenem (JDB-1-200) is an inhibitor of KPC-2 and CTX-M-15, with IC₅₀ values of 210 nM and 215 nM, respectively, and is not readily hydrolyzed by these two enzymes^[1].
8-epi-Meropenem forms covalent acyl-enzyme complexes with KPC-2^E166Q and CTX-M-15, in which the flipped 8S-hydroxyl hydrogen forms a hydrogen bond with the deacylating water molecule, at a distance of 2.9 Å in KPC-2 and 2.6 Å in CTX-M-15^[1].

Bacterial Infection

8-epi-Meropenem (0.03-32 μg/mL; 16-20 h) alone exhibited MICs of 0.5-1 μg/mL against several KPC-producing K. pneumoniae and C. freundii strains, and 4 μg/mL avibactam enhanced its activity against selected KPC- and SME-producing Enterobacterales^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 3063333-21-8
Molecular Weight 383.46
Formula C₁₇H₂₅N₃O₅S
SMILES

O=C(C(N12)=C(S[C@@H]3CN[C@H](C(N(C)C)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@@H](O)C)C1=O)O
Synonyms

JDB-1-200
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hassan T, et al. JDB-1-200, an Atypically Modified Carbapenem with Standalone In Vitro Activity against KPC-Producing Enterobacterales. ACS Infectious Diseases. 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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