8-epi-Meropenem
8-epi-Meropenem (JDB-1-200) is a Meropenem (HY-13678) derivative with antibacterial activity. 8-epi-Meropenem is an inhibitor of KPC-2 (IC50 210 nM) and CTX-M-15 (IC50 215 nM). 8-epi-Meropenem also acts on bacterial PBPs to interfere with peptidoglycan synthesis. 8-epi-Meropenem has in vitro activity against KPC-producing Enterobacterales, exhibits strain-dependent activity against Acinetobacter baumannii, and has reduced activity against Pseudomonas aeruginosa. 8-epi-Meropenem can be used for research related to bacterial infections.
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- CAS No.: 3063333-21-8
- Formule: C17H25N3O5S
- Masse moléculaire:383.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
8-epi-Meropenem forms covalent acyl-enzyme complexes with KPC-2E166Q and CTX-M-15, in which the flipped 8S-hydroxyl hydrogen forms a hydrogen bond with the deacylating water molecule, at a distance of 2.9 Å in KPC-2 and 2.6 Å in CTX-M-15[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3063333-21-8
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Masse moléculaire 383.46
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Formule C17H25N3O5S
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SMILES
O=C(C(N12)=C(S[C@@H]3CN[C@H](C(N(C)C)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@@H](O)C)C1=O)O
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Synonyms
JDB-1-200
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-epi-Meropenem Related Classifications
HY-13678B Related Classifications
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Keywords
- 8-epi-Meropenem
- 3063333-21-8
- JDB-1-200
- Bacterial
- Beta-lactamase
- Drug Derivative
- β-lactamase
- Drug derivative
- CTX-M-15
- Citrobacter freundii
- Gram-negative bacteria
- Gram-positive bacteria
- KPC-2
- Klebsiella pneumoniae
- acyl-enzyme
- anaerobic bacteria
- carbapenem-resistant enterobacterales
- deacylation
- Inhibitor
- inhibitor
- inhibit