AZD3229 Tosylate

Name: AZD3229 Tosylate
Brand: MedChemExpress
SKU: HY-112802A
Rating: 4.5 (1 reviews)

Cat. No.: HY-112802A Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

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AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

For research use only. We do not sell to patients.

AZD3229 Tosylate Chemical Structure

CAS No. : 2248003-71-4

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 185	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 530	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1480	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of AZD3229 Tosylate:

AZD3229 In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

IC₅₀ & Target

KIT^[1].

In Vitro

AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI₅₀=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

651.71

Formula

C₃₁H₃₄FN₇O₆S

CAS No.

2248003-71-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (153.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5344 mL	7.6721 mL	15.3442 mL
5 mM	0.3069 mL	1.5344 mL	3.0688 mL
10 mM	0.1534 mL	0.7672 mL	1.5344 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) LCMS (270 KB)

Handling Instructions (2659 KB)

References

[1]. Kettle JG, et al. Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J Med Ch [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5344 mL	7.6721 mL	15.3442 mL	38.3606 mL
	5 mM	0.3069 mL	1.5344 mL	3.0688 mL	7.6721 mL
	10 mM	0.1534 mL	0.7672 mL	1.5344 mL	3.8361 mL
	15 mM	0.1023 mL	0.5115 mL	1.0229 mL	2.5574 mL
	20 mM	0.0767 mL	0.3836 mL	0.7672 mL	1.9180 mL
	25 mM	0.0614 mL	0.3069 mL	0.6138 mL	1.5344 mL
	30 mM	0.0511 mL	0.2557 mL	0.5115 mL	1.2787 mL
	40 mM	0.0384 mL	0.1918 mL	0.3836 mL	0.9590 mL
	50 mM	0.0307 mL	0.1534 mL	0.3069 mL	0.7672 mL
	60 mM	0.0256 mL	0.1279 mL	0.2557 mL	0.6393 mL
	80 mM	0.0192 mL	0.0959 mL	0.1918 mL	0.4795 mL
	100 mM	0.0153 mL	0.0767 mL	0.1534 mL	0.3836 mL