1. Protein Tyrosine Kinase/RTK
  2. c-Kit

AZD3229 Tosylate 

Cat. No.: HY-112802A
Handling Instructions

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

For research use only. We do not sell to patients.

AZD3229 Tosylate Chemical Structure

AZD3229 Tosylate Chemical Structure

CAS No. : 2248003-71-4

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

IC50 & Target

KIT[1].

In Vitro

AZD3229 Tosylate is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). AZD3229 Tosylate demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5344 mL 7.6721 mL 15.3442 mL
5 mM 0.3069 mL 1.5344 mL 3.0688 mL
10 mM 0.1534 mL 0.7672 mL 1.5344 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

651.71

Formula

C₃₁H₃₄FN₇O₆S

CAS No.

2248003-71-4

SMILES

COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AZD3229 Tosylate
Cat. No.:
HY-112802A
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AZD3229 Tosylate

Cat. No.: HY-112802A