Ubavitinib tosylate
Based on 1 Customer Validation
AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.
For research use only. We do not sell to patients.
- Purity: 98.83%
- CAS No.: 2248003-71-4
- Formula: C31H34FN7O6S
- Molecular Weight:651.71
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
KIT[1].
AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2248003-71-4
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Appearance Solid
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Molecular Weight 651.71
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Formula C31H34FN7O6S
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Color Light yellow to yellow
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SMILES
COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5
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Synonyms
AZD3229 tosylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (153.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5344 mL | 7.6721 mL | 15.3442 mL | 38.3606 mL |
| 5 mM | 0.3069 mL | 1.5344 mL | 3.0688 mL | 7.6721 mL | |
| 10 mM | 0.1534 mL | 0.7672 mL | 1.5344 mL | 3.8361 mL | |
| 15 mM | 0.1023 mL | 0.5115 mL | 1.0229 mL | 2.5574 mL | |
| 20 mM | 0.0767 mL | 0.3836 mL | 0.7672 mL | 1.9180 mL | |
| 25 mM | 0.0614 mL | 0.3069 mL | 0.6138 mL | 1.5344 mL | |
| 30 mM | 0.0511 mL | 0.2557 mL | 0.5115 mL | 1.2787 mL | |
| 40 mM | 0.0384 mL | 0.1918 mL | 0.3836 mL | 0.9590 mL | |
| 50 mM | 0.0307 mL | 0.1534 mL | 0.3069 mL | 0.7672 mL | |
| 60 mM | 0.0256 mL | 0.1279 mL | 0.2557 mL | 0.6393 mL | |
| 80 mM | 0.0192 mL | 0.0959 mL | 0.1918 mL | 0.4795 mL | |
| 100 mM | 0.0153 mL | 0.0767 mL | 0.1534 mL | 0.3836 mL |
Ubavitinib tosylate Related Classifications
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