1. Apoptosis
  2. Apoptosis
  3. BLM-IN-1

BLM-IN-1 

Cat. No.: HY-111756 Purity: 99.08%
Handling Instructions

BLM-IN-1 (compound 29) is an effective Bloom syndrome protein (BLM) inhibitor, with a strong BLM binding KD of 1.81 μM and an IC50 of 0.95 μM for BLM. Induces DNA damage response, as well as apoptosis and proliferation arrest in cancer cells.

For research use only. We do not sell to patients.

BLM-IN-1 Chemical Structure

BLM-IN-1 Chemical Structure

CAS No. : 2056014-40-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 504 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BLM-IN-1 (compound 29) is an effective Bloom syndrome protein (BLM) inhibitor, with a strong BLM binding KD of 1.81 μM and an IC50 of 0.95 μM for BLM. Induces DNA damage response, as well as apoptosis and proliferation arrest in cancer cells[1].

IC50 & Target

IC50: 1.95 μM (BLM)[1].

Molecular Weight

462.60

Formula

C₂₈H₃₅FN₄O

CAS No.

2056014-40-3

SMILES

CCN(CC)CCCNC1=CC(N=C(/C(CC2)=C/C3=CC=C(C(C)C)C=C3)N2C4=O)=C4C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1617 mL 10.8085 mL 21.6169 mL
5 mM 0.4323 mL 2.1617 mL 4.3234 mL
10 mM 0.2162 mL 1.0808 mL 2.1617 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BLM-IN-1ApoptosisInhibitorinhibitorinhibit

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Product Name:
BLM-IN-1
Cat. No.:
HY-111756
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