Art. -Nr.: HY-N0111

Coenzyme Q10

Name: Coenzyme Q10
Brand: MedChemExpress
SKU: HY-N0111
Price: 30.00 USD
Availability: InStock
Rating: 5 (17 reviews)

(Synonyms: CoQ10; Ubiquinone-10; Ubidecarenone)

17 Cited Publications

Kundenbewertung

Based on 17 publication(s) in Google Scholar

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

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Reinheit : 99.97%
CAS. Nr.: 303-98-0
Formel: C₅₉H₉₀O₄
Molecular Weight:863.34

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Coenzyme Q10 Chemical Structure

CAS. Nr.: 303-98-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (17)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	GI₅₀	220 μM Compound: Coenzyme Q10	Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay	[PMID: 22137789]

In Vitro

Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state^[1]. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Because of its hydrophobicity and large molecular weight, absorption of dietary Coenzyme Q10 is slow and limited. In the case of dietary supplements, solubilized Coenzyme Q10 formulations show enhanced bioavailability. The Tmax is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma Coenzyme Q10 range from 0.40 to 1.91 mM in healthy subjects. With Coenzyme Q10 supplements there is reasonable correlation between increase in plasma Coenzyme Q10 and ingested dose up to a certain point. Animal data show that Coenzyme Q10 in large doses is taken up by all tissues including heart and brain mitochondria^[2]. In 12-month-old rats administration of coenzyme Q10 results in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly attenuates striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increases life span in a transgenic mouse model of familial amyotrophic lateral sclerosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 303-98-0
Appearance Solid
Molecular Weight 863.34
Formel C₅₉H₉₀O₄
Color Yellow to orange
SMILES

O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(OC)=C1OC)=O
Synonyms

CoQ10; Ubiquinone-10; Ubidecarenone
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (17)

All Cell Proliferation/Viability AssayBio/Physico-chemical AssayWB

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Journal Impact Factor

Cell Host Microbe

Gut-microbiota-derived indole sulfate promotes heart failure in chronic kidney disease. [Abstract]

2025 Oct 8;33(10):1715-1730.e5. PMID: 40961933
ACS Nano

Exploring Metabolic Abnormalities of Amino Acids in Preeclampsia-Associated Cardiac Physiological Dysfunction via Cardiomyocyte-Based Multimodal Biosensing. [Abstract]

2025 Sep 30;19(38):33828-33840. PMID: 40939054

Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 30;19(38):33828-33840. [Abstract]

CoQ10 (40 μM). Ca²⁺ fluorescence intensity profiles were analyzed for the following treatment groups after 24 h.

Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 30;19(38):33828-33840. [Abstract]

EFP signals recording from cardiomyocytes of different groups following CoQ10 (20-40 μM) treatment at 0, 24, and 48 h.
ACS Nano

Unveiling the Heart's Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip. [Abstract]

2024 Nov 12;18(45):31569-31585. PMID: 39482939
J Nanobiotechnology

A core-shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing. [Abstract]

2026 Mar 17;24(1):389. PMID: 41845345
Cancer Lett

Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression. [Abstract]

2025 Oct 10:630:217903. PMID: 40618880

Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Oct 10:630:217903. [Abstract]

CCK8 assay to detect the cell viability of indicated OVCAR-5 treated with coenzyme Q10 (0-200 μM, 72 h).
Mol Psychiatry

Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling. [Abstract]

2025 Sep 16. PMID: 40954280
Int J Nanomedicine

Aptamer Functionalized Liposomes Co-Loaded with Exenatide-4 and Coenzyme Q10 Ameliorate Type 2 Diabetes Mellitus by Improving Pancreatic β Cell Function. [Abstract]

2025 Mar 17:20:3363-3378. PMID: 40125440
Free Radic Biol Med

IL-6/STAT3 signaling drives mitochondrial oxidative phosphorylation dysfunction and AP-1 activation in fibroblasts during sepsis-induced lung injury. [Abstract]

2026 May 26:253:148-163. PMID: 42191040
Br J Pharmacol

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]

2025 May 13. PMID: 40361281
Commun Biol

ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes. [Abstract]

2023 Nov 25;6(1):1201. PMID: 38007539

Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Nov 25;6(1):1201. [Abstract]

CoQ10 (20 μM). ATP level in MES23.5 cells. The endogenous ATP level was detected by luminescent cell viability assay, and the data expressed as a percentage of the Con. n = 4.

Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Nov 25;6(1):1201. [Abstract]

CoQ10 (10-20 μM). Expression levels of H3K9ac and H4K5ac in TA-treated MES23.5 cells were determined by Western blotting.
Int J Antimicrob Agents

SU3327: A multi-target compound targeting bacterial menaquinone and DNA. [Abstract]

2025 Nov 25;67(1):107679. PMID: 41308844
PLoS Pathog

2026 Jul 7;22(7):e1014392. PMID: 42412894
Environ Toxicol Pharmacol

Assessment of the toxicity of acrolein on an alveolus microphysiological system. [Abstract]

2026 Mar:122:104954. PMID: 41644025
J Biochem Mol Toxicol

Protective effect and mechanism of CoQ10 in mitochondrial dysfunction in diquat-induced renal proximal tubular injury. [Abstract]

2024 Nov;38(11):e70023. PMID: 39434449
J Egypt Natl Canc Inst

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation. [Abstract]

2025 Mar 10;37(1):7. PMID: 40059278
Res Sq

2025 Oct 9.
bioRxiv

2024 July 31.

Lösungsmittel & Löslichkeit

In Vitro:

DMF : 20 mg/mL (23.17 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 2.5 mg/mL (2.90 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1583 mL

5.7915 mL

11.5829 mL

5 mM

0.2317 mL

1.1583 mL

2.3166 mL

10 mM

0.1158 mL

0.5791 mL

1.1583 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMF 90% (20% SBE-β-CD in Saline)

Solubility: 3 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 15% Cremophor EL 85% Saline

Solubility: 10 mg/mL (11.58 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang YK, et al. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin Chim Acta. 2015 Oct 23;450:83-9. [Content Brief]

[2]. Bhagavan HN, et al. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006 May;40(5):445-53. [Content Brief]

[3]. Matthews RT, et al. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8892-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMF	1 mM	1.1583 mL	5.7915 mL	11.5829 mL	28.9573 mL
DMF	5 mM	0.2317 mL	1.1583 mL	2.3166 mL	5.7915 mL
	10 mM	0.1158 mL	0.5791 mL	1.1583 mL	2.8957 mL
	15 mM	0.0772 mL	0.3861 mL	0.7722 mL	1.9305 mL
	20 mM	0.0579 mL	0.2896 mL	0.5791 mL	1.4479 mL

Bioz

Keywords

Coenzyme Q10

17 Cited Publications

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Coenzyme Q10

Publications Citing Use of MedChemExpress (MCE) Coenzyme Q10

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen