1. Apoptosis
  2. Apoptosis
  3. Costunolide

Costunolide (Synonyms: (+)-Costunolide; Costus lactone)

製品番号: HY-N0036 純度: 99.84%
取扱説明書

Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.

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Costunolide 構造式

Costunolide 構造式

CAS 番号 : 553-21-9

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 79 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 108 在庫あり
Estimated Time of Arrival: December 31
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Costunolide purchased from MCE. Usage Cited in: Gene. 2018 Dec 15;678:261-269.

    Western blot analysis of mTOR phosphorylation at Ser2448 and Ser2481 with quantification.
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    製品説明

    Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis. IC50 Value: 6.2 - 9.8 ug/mL(sarcoma cells viability)[3] Target: Apoptosis inducer in vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and its downstream target PARP [2]. Both costunolide and dehydrocostus lactone inhibited cell viability dose- and time-dependently. IC50 values ranged from 6.2 ug/mL to 9.8 ug/mL. Cells treated with costunolide showed no changes in cell cycle, little in caspase 3/7 activity, and low levels of cleaved caspase-3 after 24 and 48 h [3]. in vivo: Neither costunolide nor alpha-MGBL affected the blood-ethanol elevation in pylorus-ligated rats or that induced by intraperitoneal and intraduodenal ethanol administration [4]. Costunolide and alpha-MGBL suppressed gastric emptying in rats given 20% ethanol and 1% sodium carboxymethyl cellulose. Clinical trial:

    分子量

    232.32

    分子式

    C₁₅H₂₀O₂

    CAS 番号

    553-21-9

    SMILES

    O=C(O[[email protected]@]1([H])[[email protected]@]2([H])CC/C(C)=C/CC/C(C)=C/1)C2=C

    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 49 mg/mL (210.92 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3044 mL 21.5220 mL 43.0441 mL
    5 mM 0.8609 mL 4.3044 mL 8.6088 mL
    10 mM 0.4304 mL 2.1522 mL 4.3044 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.58 mg/mL (11.11 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.58 mg/mL (11.11 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.58 mg/mL (11.11 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献

    純度: 99.84%

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    Keywords:

    Costunolide(+)-Costunolide Costus lactoneApoptosisInhibitorinhibitorinhibit

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    製品名:
    Costunolide
    製品番号:
    HY-N0036
    数量:
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