1. Apoptosis
    Metabolic Enzyme/Protease
  2. Apoptosis
    Endogenous Metabolite
  3. Costunolide

Costunolide (Synonyms: (+)-Costunolide; Costus lactone)

製品番号: HY-N0036 純度: 99.84%
取扱説明書

Costunolide ((+)-Costunolide; Costus lactone) is a bioactive sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells.

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Costunolide 構造式

Costunolide 構造式

CAS 番号 : 553-21-9

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 79 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 108 在庫あり
Estimated Time of Arrival: December 31
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Costunolide purchased from MCE. Usage Cited in: Gene. 2018 Dec 15;678:261-269.

    Western blot analysis of mTOR phosphorylation at Ser2448 and Ser2481 with quantification.
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    製品説明

    Costunolide ((+)-Costunolide; Costus lactone) is a bioactive sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Costunolide inhibits the colony formation, migrative and invasive abilities of the H1299 cells in a dose or time dependent manner[2].
    Costunolide (6.7-215.2 μM; 24 hours) inhibits the viability of H1299 cells in a dose-dependent manner, with an IC50 of 23.93 µM[2].
    Costunolide (12.0-48.0 µM; 48 hours) induces apoptosis in H1299 cells[2].
    Costunolide (12-48.0 µM; 6-12 hours) regulates metastasis- and proliferation-associated mRNA expression[2].
    Costunolide regulates epithelial-to-mesenchymal transition (EMT)-associated protein expression[2].
    Costunolide regulates c-Myc mediated apoptosis signaling and 14-3-3-mediated signaling pathways in breast cancer cells[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: H1299 cells
    Concentration: 6.7 μM, 13.5 μM, 26.9 μM, 107.6 μM, 215.2 μM
    Incubation Time: 24 hours
    Result: Inhibited the viability of H1299 cells (MTT assay).

    Apoptosis Analysis[2]

    Cell Line: H1299 cells
    Concentration: 0 µM, 12.0 µM, 24.0 µM, 48.0 µM
    Incubation Time: 48 hours
    Result: The apoptotic rate was significantly different between the control at 24.0 µM and 48.0 µM.

    RT-PCR[2]

    Cell Line: H1299 cells
    Concentration: 0 µM, 12.0 µM, 24.0 µM, 48.0 µM
    Incubation Time: 6 hours, 12 hours
    Result: Regulated the metastasis- and proliferation-associated mRNA levels in a dose-dependent manner.

    Western Blot Analysis[2]

    Cell Line: H1299 cells
    Concentration: 0 µM, 12.0 µM, 24.0 µM, 48.0 µM
    Incubation Time: 48 hours
    Result: Significantly inhibited the EMT of H1299 cells.
    体内実験

    Costunolide (20 mg/kg; i.p; daily, for 30 days) inhibits breast cancer through c-Myc/p53 and AKT/14-3-3 pathway[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4 weeks old female BALB/c nude mice, MDA-MB-231 cells xenograft mouse models[3]
    Dosage: 20 mg/kg
    Administration: Intraperitoneal injection, daily, for 30 days
    Result: Reduced the expression levels of c-Myc and p-AKT and elevated the expression levels of p53 and p-14-3-3.
    分子量

    232.32

    分子式

    C₁₅H₂₀O₂

    CAS 番号

    553-21-9

    SMILES

    O=C(O[[email protected]@]1([H])[[email protected]@]2([H])CC/C(C)=C/CC/C(C)=C/1)C2=C

    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 49 mg/mL (210.92 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3044 mL 21.5220 mL 43.0441 mL
    5 mM 0.8609 mL 4.3044 mL 8.6088 mL
    10 mM 0.4304 mL 2.1522 mL 4.3044 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.58 mg/mL (11.11 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.58 mg/mL (11.11 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.58 mg/mL (11.11 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献

    純度: 99.84%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Keywords:

    Costunolide(+)-Costunolide Costus lactoneApoptosisEndogenous Metaboliteantioxidantsanti-inflammatoryanti-allergicboneregeneratingneuroprotectiveantimicrobialhairgrowthpromotinganticancerantidiabeticInhibitorinhibitorinhibit

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    製品名:
    Costunolide
    製品番号:
    HY-N0036
    数量:
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