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GF 15 

Cat. No.: HY-12797
Handling Instructions

GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

For research use only. We do not sell to patients.

GF 15 Chemical Structure

GF 15 Chemical Structure

CAS No. : 888042-13-5

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Description

GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

IC50 & Target

Centrosomal clustering[1]

In Vitro

GF 15 leads to multipolar mitosis induction with an EC50 of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC50s of 1-5 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

428.86

Formula

C₂₃H₂₁ClO₆

CAS No.

888042-13-5

SMILES

O=C1[[email protected]]2(C(OCC3=CC=CC=C3)=CC(C[[email protected]]2C)=O)OC4=C(Cl)C(OC)=CC(OC)=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

Hela cells are treated with GF 15 (0, 0.25, 0.5, 0.75, 1, 1.25 μM) for 24 and/or 48 hours. Cell viability is examined using the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice[1]

Beige-nude Xid mice are inoculated s.c. in the right flank with 3×106 OPM2 or HT29 cells. When a tumor is measurable, mice are assigned to a GF 15 treatment group (20, 100 mg/kg) or the control group for 0-20 days. Tumor burden is measured every alternating day using an electronic caliper.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

GF 15GF15GF-15OthersInhibitorinhibitorinhibit

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GF 15
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