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GF 15 

Cat. No.: HY-12797
Handling Instructions

GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

For research use only. We do not sell to patients.

GF 15 Chemical Structure

GF 15 Chemical Structure

CAS No. : 888042-13-5

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Description

GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

IC50 & Target

Centrosomal clustering[1]

In Vitro

GF 15 leads to multipolar mitosis induction with an EC50 of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC50s of 1-5 μM[1].

In Vivo

Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival[1].

Molecular Weight

428.86

Formula

C₂₃H₂₁ClO₆

CAS No.

888042-13-5

SMILES

O=C1[[email protected]]2(C(OCC3=CC=CC=C3)=CC(C[[email protected]]2C)=O)OC4=C(Cl)C(OC)=CC(OC)=C14

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

Hela cells are treated with GF 15 (0, 0.25, 0.5, 0.75, 1, 1.25 μM) for 24 and/or 48 hours. Cell viability is examined using the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice[1]

Beige-nude Xid mice are inoculated s.c. in the right flank with 3×106 OPM2 or HT29 cells. When a tumor is measurable, mice are assigned to a GF 15 treatment group (20, 100 mg/kg) or the control group for 0-20 days. Tumor burden is measured every alternating day using an electronic caliper.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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GF 15
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