GF 15

Cat. No.: HY-12797: FAQs
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GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

For research use only. We do not sell to patients.

GF 15 Chemical Structure

CAS No. : 888042-13-5

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Description	GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.
IC₅₀ & Target	Centrosomal clustering^[1]
In Vitro	GF 15 leads to multipolar mitosis induction with an EC₅₀ of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC₅₀s of 1-5 μM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. GF 15 Related Antibodies
In Vivo	Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	428.86
Formula	C₂₃H₂₁ClO₆
CAS No.	888042-13-5
SMILES	O=C1[C@]2(C(OCC3=CC=CC=C3)=CC(C[C@H]2C)=O)OC4=C(Cl)C(OC)=CC(OC)=C14
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (276 KB) Handling Instructions (2659 KB)
References	[1]. Raab MS, et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2012 Oct 15;72(20):5374-85. [Content Brief]

Cell Assay ^[1]	Hela cells are treated with GF 15 (0, 0.25, 0.5, 0.75, 1, 1.25 μM) for 24 and/or 48 hours. Cell viability is examined using the MTT assay^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Mice^[1] Beige-nude Xid mice are inoculated s.c. in the right flank with 3×10⁶ OPM2 or HT29 cells. When a tumor is measurable, mice are assigned to a GF 15 treatment group (20, 100 mg/kg) or the control group for 0-20 days. Tumor burden is measured every alternating day using an electronic caliper. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Raab MS, et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2012 Oct 15;72(20):5374-85. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GF 15888042-13-5GF15GF-15OthersInhibitorinhibitorinhibit

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GF 15

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