Hexylene glycol
Based on 1 Customer Validation
Hexylene glycol is a low molecular weight surfactant with antimicrobial properties. Hexylene glycol is widely used in industrial chemicals and cosmetics.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 107-41-5
- Formula: C6H14O2
- Molecular Weight:118.18
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Hexylene glycol at 10% and 30% concentrations killed Candida albicans, Staphylococcus aureus, Staphylococcus epidermidis, Group A Streptococcus, Streptococcus parvus, and Escherichia coli in fresh tryptone agar within 20 hours. Hexylene glycol at 5% concentration showed some antimicrobial activity, but hexylene glycol at 1% concentration had no effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 107-41-5
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Appearance Liquid (Density: 0.925 g/cm3)
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Molecular Weight 118.18
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Formula C6H14O2
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Color Colorless to light yellow
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SMILES
CC(O)(C)CC(O)C
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Synonyms
2-Methyl-2,4-pentanediol; MPD
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (846.17 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (846.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (21.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (21.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (846.17 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Kinnunen T, et al. Antibacterial and antifungal properties of propylene glycol, hexylene glycol, and 1, 3-butylene glycol in vitro[J]. Acta dermato-venereologica, 1991, 71(2): 148-150. [Content Brief]
[2]. Kinnunen T, et al. Skin reactions to hexylene glycol[J]. Contact Dermatitis, 1989, 21(3): 154-158. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.4617 mL | 42.3083 mL | 84.6167 mL | 211.5417 mL |
| 5 mM | 1.6923 mL | 8.4617 mL | 16.9233 mL | 42.3083 mL | |
| 10 mM | 0.8462 mL | 4.2308 mL | 8.4617 mL | 21.1542 mL | |
| 15 mM | 0.5641 mL | 2.8206 mL | 5.6411 mL | 14.1028 mL | |
| 20 mM | 0.4231 mL | 2.1154 mL | 4.2308 mL | 10.5771 mL | |
| 25 mM | 0.3385 mL | 1.6923 mL | 3.3847 mL | 8.4617 mL | |
| 30 mM | 0.2821 mL | 1.4103 mL | 2.8206 mL | 7.0514 mL | |
| 40 mM | 0.2115 mL | 1.0577 mL | 2.1154 mL | 5.2885 mL | |
| 50 mM | 0.1692 mL | 0.8462 mL | 1.6923 mL | 4.2308 mL | |
| 60 mM | 0.1410 mL | 0.7051 mL | 1.4103 mL | 3.5257 mL | |
| 80 mM | 0.1058 mL | 0.5289 mL | 1.0577 mL | 2.6443 mL | |
| 100 mM | 0.0846 mL | 0.4231 mL | 0.8462 mL | 2.1154 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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