1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. JNJ-54175446

JNJ-54175446 

Cat. No.: HY-117508
Handling Instructions

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.

For research use only. We do not sell to patients.

JNJ-54175446 Chemical Structure

JNJ-54175446 Chemical Structure

CAS No. : 1627902-21-9

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Description

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.

IC50 & Target

pIC50: 8.46 (hP2X7 receptor), 8.81 (rP2X7 receptor)[1]

In Vitro

JNJ-54175446 (Compound 14) is a potent and selective brain penetrant P2X7 antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 and rP2X7, respectively. JNJ-54175446 shows less potent activity against mouse, dog and Macaque P2X7 (pIC50, 7.8, 7.9 and 8.1, respectively)[1].

In Vivo

JNJ-54175446 shows dose-dependent occupancy with the ED50 of 0.46 mg/kg, corresponding to plasma EC50 of 105 ng/mL[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

440.78

Formula

C₁₈H₁₃ClF₄N₆O

CAS No.

1627902-21-9

SMILES

ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[[email protected]]2C)=O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

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JNJ-54175446
Cat. No.:
HY-117508
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Cat. No.: HY-117508