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LDN-27219 

Cat. No.: HY-16693 Purity: 99.64%
Handling Instructions

LDN-27219 is a potent inhibitor of hTGase(Tissue transglutaminase) with an IC50 of 0.6 uM.

For research use only. We do not sell to patients.

LDN-27219 Chemical Structure

LDN-27219 Chemical Structure

CAS No. : 312946-37-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 167 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 167 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 152 In-stock
Estimated Time of Arrival: December 31
50 mg USD 642 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Description

LDN-27219 is a potent inhibitor of hTGase(Tissue transglutaminase) with an IC50 of 0.6 uM. IC50 value: 0.6 uM [1] Target: hTGase inhibitor LDN-27219 is a potent inhibitor of the enzyme(hTGase), producing 100% inhibition at the screening concentration of 10 uM. To examine the enzyme selectivity of LDN-27219, it was tested as an inhibitor of coagulation Factor XIIIa and caspase 3. At concentrations as high as 50 íM, the compound had no effect on the activities of either of these enzymes. LDN-27219 was found to be nontoxic at concentrations as high as 100 íM in an assay that measures the viability of HT1080 cells, a fibrosarcoma tumor cell line.

Molecular Weight

408.50

Formula

C20H16N4O2S2

CAS No.
SMILES

O=C1N(C2=CC=CC=C2)C(SCC(NN)=O)=NC3=C1C(C4=CC=CC=C4)=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (306.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4480 mL 12.2399 mL 24.4798 mL
5 mM 0.4896 mL 2.4480 mL 4.8960 mL
10 mM 0.2448 mL 1.2240 mL 2.4480 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.64%

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Product Name:
LDN-27219
Cat. No.:
HY-16693
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