M2 ion channel blocker-1
M2 ion channel blocker-1 is an inhibitor of the M2 ion channel, with activity against the wild-type, S31N mutant, and S31N-L26I mutant of the M2 ion channel. M2 ion channel blocker-1 can be used in studies related to influenza A.
For research use only. We do not sell to patients.
- CAS No.: 1190215-03-2
- Formula: C18H27N3O2
- Molecular Weight:317.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
M2 ion channel blocker-1 (compound 7) (0.01-1000 μM; >30 s) inhibits WT M2 ion channels expressed in 293T-rex cells with an IC50 of 18.9 μM, inhibits M2S31N-L26I mutant ion channels with an IC50 of 112.1 μM, and has an undetermined IC50 for M2S31N mutant ion channels[1].
M2 ion channel blocker-1 (72 h) shows low cytotoxicity to 293T-rex cells expressing WT, S31N mutant, and S31N-L26I mutant M2 ion channels with CC50 values of 463.1 μM, 399.7 μM, and >500 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1190215-03-2
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Appearance Solid
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Molecular Weight 317.43
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Formula C18H27N3O2
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Color Light brown to brown
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SMILES
O=C(OC)[C@H](CC1C=NC=N1)NCC2(C[C@H]3C4)C[C@H]4C[C@H](C3)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Two-electrode voltage clamp in Xenopus oocytes
Two-electrode voltage clamp measures whole-oocyte membrane current from Xenopus oocytes expressing exogenous ion channels, receptors, or transporters; one intracellular microelectrode senses membrane voltage, and the second injects current so the amplifier can hold the membrane at command voltages while recording the compensating current as the functional readout. The method is suited to Xenopus oocytes because their large size supports microinjection and intracellular electrode impalement, but the large membrane area can limit voltage-clamp speed and accuracy, especially for large or fast currents.
Purity & Documentation
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Data Sheet (291 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
M2 ion channel blocker-1 Related Classifications
HY-75867 Related Classifications
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