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Cat. No.: HY-75867

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M2 ion channel blocker-1

M2 ion channel blocker-1 is an inhibitor of the M2 ion channel, with activity against the wild-type, ^S31N mutant, and ^S31N-L26I mutant of the M2 ion channel. M2 ion channel blocker-1 can be used in studies related to influenza A.

For research use only. We do not sell to patients.

CAS No.: 1190215-03-2
Formula: C₁₈H₂₇N₃O₂
Molecular Weight:317.43

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

M2 ion channel blocker-1 Chemical Structure

CAS No.: 1190215-03-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

M2 ion channel blocker-1 (compound 7) (0.01-1000 μM; >30 s) inhibits WT M2 ion channels expressed in 293T-rex cells with an IC₅₀ of 18.9 μM, inhibits M2^S31N-L26I mutant ion channels with an IC₅₀ of 112.1 μM, and has an undetermined IC₅₀ for M2^S31N mutant ion channels^[1].
M2 ion channel blocker-1 (72 h) shows low cytotoxicity to 293T-rex cells expressing WT, S31N mutant, and S31N-L26I mutant M2 ion channels with CC₅₀ values of 463.1 μM, 399.7 μM, and >500 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1190215-03-2
Appearance Solid
Molecular Weight 317.43
Formula C₁₈H₂₇N₃O₂
Color Light brown to brown
SMILES

O=C(OC)[C@H](CC1C=NC=N1)NCC2(C[C@H]3C4)C[C@H]4C[C@H](C3)C2
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang, W. J., et al. Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A. Chinese Journal of Chemistry, 28(8), 1417‑1423.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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