2. Anti-infection
  3. Bacterial
  4. MAC13243

MAC13243 

Cat. No.: HY-14456A Purity: ≥98.0%
COA Handling Instructions

MAC13243, an antibacterial agent, is an inhibitor of bacterial lipoprotein targeting chaperone, LolA. MAC13243 is an antibacterial agent with Gram-negative selectivity.

For research use only. We do not sell to patients.

MAC13243 Chemical Structure

MAC13243 Chemical Structure

CAS No. : 1071638-38-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 407 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 407 In-stock
Solid
5 mg USD 370 In-stock
10 mg USD 552 In-stock
50 mg USD 1234 In-stock
100 mg USD 1974 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MAC13243

Proliferation Assay

    MAC13243 purchased from MCE. Usage Cited in: Sci Rep. 2017 Dec 15;7(1):17629.  [Abstract]

    E. coli MC4100 are grown in M9 media then exposed to different concentrations of MAC13234 (MIC=256 μg/mL) and NPN uptake was monitored (left panel). The increase in fluorescence is deemed to be due to increased permeability of the outer membrane, not cell lysis, since the amount of MAC13243 used does not affect cell viability (right panel).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MAC13243, an antibacterial agent, is an inhibitor of bacterial lipoprotein targeting chaperone, LolA. MAC13243 is an antibacterial agent with Gram-negative selectivity[1][2].

    Molecular Weight

    442.40

    Appearance

    Solid

    Formula

    C20H25Cl2N3O2S
    CAS No.
    SMILES

    ClC1=CC=C(CSC2=NCN(CCC3=CC(OC)=C(OC)C=C3)CN2)C=C1.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (113.02 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2604 mL 11.3020 mL 22.6040 mL
    5 mM 0.4521 mL 2.2604 mL 4.5208 mL
    10 mM 0.2260 mL 1.1302 mL 2.2604 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    MAC132431071638-38-4MAC 13243MAC-13243BacterialInhibitorinhibitorinhibit

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