1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. Drug-Linker Conjugates for ADC
    Microtubule/Tubulin

Mc-MMAD (Synonyms: Mc MMAD; McMMAD)

Cat. No.: HY-15740
Handling Instructions

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -conjugated MMAD.

For research use only. We do not sell to patients.
Mc-MMAD Chemical Structure

Mc-MMAD Chemical Structure

CAS No. : 1401963-15-2

Size Price Stock Quantity
1 mg $550 In-stock
5 mg $930 In-stock
10 mg $1425 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -conjugated MMAD. IC50 Value: Target: tubulin; ADCs For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.0371 mL 5.1853 mL 10.3706 mL
5 mM 0.2074 mL 1.0371 mL 2.0741 mL
10 mM 0.1037 mL 0.5185 mL 1.0371 mL
References
M.Wt

964.26

Formula

C₅₁H₇₇N₇O₉S

CAS No.

1401963-15-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Mc-MMAD
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HY-15740
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