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Neuropathiazol 

Cat. No.: HY-10591 Purity: 98.27%
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Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.

For research use only. We do not sell to patients.

Neuropathiazol Chemical Structure

Neuropathiazol Chemical Structure

CAS No. : 880090-88-0

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Solution
10 mM * 1 mL in DMSO USD 161 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 161 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 146 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1068 In-stock
Estimated Time of Arrival: December 31
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Description

Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells[1].

In Vitro

Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects[1].
Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker)[1].
Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2[1].
Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells[1].
Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HCN cells
Concentration: 5 μM, 10 μM, 15 μM
Incubation Time: 5 hours
Result: Inhibited proliferation of HCN neural progenitor cells.

RT-PCR[1]

Cell Line: HCN cells
Concentration: 10 μM
Incubation Time: 1 day, 4 days
Result: Downregulated Sox2 and upregulated NeuroD1.
Molecular Weight

338.42

Formula

C₁₉H₁₈N₂O₂S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (98.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9549 mL 14.7745 mL 29.5491 mL
5 mM 0.5910 mL 2.9549 mL 5.9098 mL
10 mM 0.2955 mL 1.4775 mL 2.9549 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Neuropathiazol
Cat. No.:
HY-10591
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