1. PROTAC
  2. PROTAC Linker

PROTAC Linker 1 

Cat. No.: HY-108371 Purity: >98.0%
Handling Instructions

PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

For research use only. We do not sell to patients.

PROTAC Linker 1 Chemical Structure

PROTAC Linker 1 Chemical Structure

CAS No. : 1835705-53-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

In Vitro

PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. PROTAC Linker 1 is designated as 6-2-2[1].

References
Molecular Weight

294.81

Formula

C₁₄H₂₇ClO₄

CAS No.

1835705-53-7

SMILES

O=C(OC(C)(C)C)COCCOCCCCCCCl

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PROTAC Linker 1
Cat. No.:
HY-108371
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PROTAC Linker 1

Cat. No.: HY-108371