1. PROTAC
  2. PROTAC Linker
  3. PROTAC Linker 1

PROTAC Linker 1 

Cat. No.: HY-108371 Purity: >98.0%
Handling Instructions

PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

For research use only. We do not sell to patients.

PROTAC Linker 1 Chemical Structure

PROTAC Linker 1 Chemical Structure

CAS No. : 1835705-53-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

IC50 & Target

Alkyl/ether

 

In Vitro

PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. PROTAC Linker 1 is designated as 6-2-2[1].

Molecular Weight

294.81

Formula

C₁₄H₂₇ClO₄

CAS No.

1835705-53-7

SMILES

O=C(OC(C)(C)C)COCCOCCCCCCCl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (169.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3920 mL 16.9601 mL 33.9202 mL
5 mM 0.6784 mL 3.3920 mL 6.7840 mL
10 mM 0.3392 mL 1.6960 mL 3.3920 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
PROTAC Linker 1
Cat. No.:
HY-108371
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