2. PROTAC
  3. PROTAC Linkers
  4. Boc-C1-PEG2-C4-Cl

Boc-C1-PEG2-C4-Cl  (Synonyms: PROTAC Linker 1)

Cat. No.: HY-108371 Purity: 99.81%
COA Handling Instructions

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Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Boc-C1-PEG2-C4-Cl Chemical Structure

Boc-C1-PEG2-C4-Cl Chemical Structure

CAS No. : 1835705-53-7

Size Price Stock Quantity
25 mg USD 80 In-stock
50 mg USD 130 In-stock
100 mg USD 210 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Boc-C1-PEG2-C4-Cl Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. Boc-C1-PEG2-C4-Cl is designated as 6-2-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-C1-PEG2-C4-Cl Related Antibodies
Molecular Weight

294.81

Formula

C14H27ClO4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)COCCOCCCCCCCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (169.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3920 mL 16.9601 mL 33.9202 mL
5 mM 0.6784 mL 3.3920 mL 6.7840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3920 mL 16.9601 mL 33.9202 mL 84.8004 mL
5 mM 0.6784 mL 3.3920 mL 6.7840 mL 16.9601 mL
10 mM 0.3392 mL 1.6960 mL 3.3920 mL 8.4800 mL
15 mM 0.2261 mL 1.1307 mL 2.2613 mL 5.6534 mL
20 mM 0.1696 mL 0.8480 mL 1.6960 mL 4.2400 mL
25 mM 0.1357 mL 0.6784 mL 1.3568 mL 3.3920 mL
30 mM 0.1131 mL 0.5653 mL 1.1307 mL 2.8267 mL
40 mM 0.0848 mL 0.4240 mL 0.8480 mL 2.1200 mL
50 mM 0.0678 mL 0.3392 mL 0.6784 mL 1.6960 mL
60 mM 0.0565 mL 0.2827 mL 0.5653 mL 1.4133 mL
80 mM 0.0424 mL 0.2120 mL 0.4240 mL 1.0600 mL
100 mM 0.0339 mL 0.1696 mL 0.3392 mL 0.8480 mL
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Boc-C1-PEG2-C4-Cl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-C1-PEG2-C4-Cl1835705-53-7PROTAC Linker 1PROTAC Linker1PROTAC Linker-1PROTAC LinkersInhibitorinhibitorinhibit

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