1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Prinoxodan

Prinoxodan (Synonyms: RGW2938)

Cat. No.: HY-U00208 Purity: 95.58%
Handling Instructions

Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.

For research use only. We do not sell to patients.

Prinoxodan Chemical Structure

Prinoxodan Chemical Structure

CAS No. : 111786-07-3

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Estimated Time of Arrival: December 31
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Description

Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.

IC50 & Target

Phosphodiesterase[1]

In Vitro

Prinoxodan (RG W-2938) is an orally effective positive inotropic/vasodilator agent. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion[2].

In Vivo

Prinoxodan (RG W-2938) is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. Prinoxodan 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR[2].

Molecular Weight

257.27

Formula

C₁₃H₁₃N₄O₂

CAS No.

111786-07-3

SMILES

O=C1NC2=C(C=C(C3=N[N]C(CC3)=O)C=C2)CN1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

PrinoxodanRGW2938RGW 2938RGW-2938Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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