1. Anti-infection
  2. RSV

RSV-IN-1 

Cat. No.: HY-112673 Purity: 99.83%
Handling Instructions

RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor, with an IC50 of 0.11 μM.

For research use only. We do not sell to patients.

RSV-IN-1 Chemical Structure

RSV-IN-1 Chemical Structure

CAS No. : 861139-16-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 759 In-stock
Estimated Time of Arrival: December 31
5 mg USD 690 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • References

Description

RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor, with an IC50 of 0.11 μM.

IC50 & Target

IC50: 0.11μM (hRSV)[1].

In Vitro

The concentration of P13 that reduces the number of RSV plaques in HEp-2 cells by 50% (IC50) is 0.11 μM. The concentration of P13 that reduces the viability of HEp-2 by 50% (CC50) is 310 μM. Note that some cytotoxicity of P13 observed at 500 μM might be due to DMSO solvent. Hence, the selective index (CC50/IC50) values is 2818 for P13. Note that even at the relatively high concentrations P13 does not completely block the development of RSV plaques. These escape plaques are of smaller size and of non-syncytial phenotype as compared to plaques formed in the absence of inhibitor[1].

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (292.41 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3393 mL 11.6965 mL 23.3929 mL
5 mM 0.4679 mL 2.3393 mL 4.6786 mL
10 mM 0.2339 mL 1.1696 mL 2.3393 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.87 mM); Clear solution

References
Molecular Weight

427.48

Formula

C₂₀H₂₁N₅O₄S

CAS No.

861139-16-4

SMILES

O=S(C1=CC=C(OC)C(C2=NN=C3N2N=C(C)C4=C3C=CC=C4)=C1)(N(CCO)C)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
RSV-IN-1
Cat. No.:
HY-112673
Quantity:

RSV-IN-1

Cat. No.: HY-112673