Rabies Virus Glycoprotein
Based on 1 publication(s) in Google Scholar
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.
For research use only. We do not sell to patients.
- Purity: 99.88%
- Formula: C141H217N43O43S2
- Molecular Weight:3266.70
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Rabies Virus Glycoprotein
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Biological Activity
RVG peptide is successfully used to carry a variety of cargos into brain cells such as plasmids, siRNAs, proteins, and nanoparticles[1]. RVG29 can govern the interaction of viral particles with at least three known receptors, including neural cell adhesion molecule (NCAM), the p75 neurotrophin receptor (P75NTR), and nicotinic acetylcholine receptors (NAChRs). The RVG29 peptide enhances the brain-specific function of a range of systemically delivered agents, particularly nucleic acids[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 3266.70
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Formula C141H217N43O43S2
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Color White to off-white
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Sequence
Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly
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Sequence Shortening
YTIWMPENPRPGTPCDIFTNSRGKRASNG
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Structure Classification
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Initial Source
Rabies Virus Glycoprotein
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Neurosci Bull
A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats. [Abstract]2021 May;37(5):669-683. PMID: 33779892
Solvent & Solubility
H2O : 100 mg/mL (30.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zou Z, et al. Cre Fused with RVG Peptide Mediates Targeted Genome Editing in Mouse Brain Cells In Vivo. Int J Mol Sci. 2016 Dec 14;17(12). pii: E2104. [Content Brief]
[2]. Cook RL, et al. A critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system. J Control Release. 2015 Dec 28;220(Pt A):89-97. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3061 mL | 1.5306 mL | 3.0612 mL | 7.6530 mL |
| 5 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5306 mL | |
| 10 mM | 0.0306 mL | 0.1531 mL | 0.3061 mL | 0.7653 mL | |
| 15 mM | 0.0204 mL | 0.1020 mL | 0.2041 mL | 0.5102 mL | |
| 20 mM | 0.0153 mL | 0.0765 mL | 0.1531 mL | 0.3826 mL | |
| 25 mM | 0.0122 mL | 0.0612 mL | 0.1224 mL | 0.3061 mL | |
| 30 mM | 0.0102 mL | 0.0510 mL | 0.1020 mL | 0.2551 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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