Cancer Targeted Therapy
Cancer targeted therapy is the foundation of precision medicine; it uses drugs or other substances to target specific genes and proteins that control cancer cells’ growth, division and spreading. Compared to traditional chemotherapy drugs, targeted-drugs can specifically act on cancer cells with high efficacy without damaging normal cells. Drugs used in cancer targeted therapy mainly includes small molecules and macromolecules (e.g., monoclonal antibodies), which can target cancer cells and constituents in the tumor microenvironment to activate the immune system. Anti-angiogenesis drugs, such as those targeting vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), transforming growth factor (TGF)-α, TGF-β, Tumor necrosis factor (TNF)-α, and platelet-derived endothelial growth factor (PDGFR) inhibit the proliferation and metastasis of cancer cells. In recent years, the proportion of antibody drugs in cancer treatment has gradually become prominent. Antibody-drug conjugates (ADCs) are a new type of targeted drugs that are composed of monoclonal antibody, cytotoxic drug and linker. ADCs can deliver drugs to tumor cells and minimize the toxicity to normal tissues. Proteolysis-targeting chimera (PROTAC) is a useful technology for targeted protein degradation. PROTAC exploits the ubiquitin-proteasome system and forms a ternary complex with a hijacked E3 ubiquitin ligase and target protein, leading to polyubiquitination and degradation of the target protein.
Targeted therapy is a useful strategy in treatment of cancer either alone or in combination with standard chemotherapy. At present, targeted therapy has proved significant clinical success in the treatment of many types of cancer, including breast cancer, colorectal cancer, leukemia, ovarian cancer and lung cancer.
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Anti-MST1R Antibody (MOR07692)
0 ImagesCat. No.: HY-P991185Purity: 99.44%
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tert-Butyl (3-(piperidin-4-yl)propyl)carbamate
0 ImagesCat. No.: HY-W583818CAS No.: 885268-87-1
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tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate
![tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w054347.gif "Click to View tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W054347CAS No.: 1363381-61-6
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10-((((9h-Fluoren-9-yl)methoxy)carbonyl)amino)decanoic acid
0 ImagesCat. No.: HY-W301135CAS No.: 143688-82-8
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tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride
0 ImagesCat. No.: HY-W056397CAS No.: 178312-58-8
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LY-2584702 free base
0 ImagesCat. No.: HY-12493CAS No.: 1082949-67-4LY-2584702 free base is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
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(9H-Fluoren-9-yl)methyl (6-hydroxyhexyl)carbamate
0 ImagesCat. No.: HY-W097011CAS No.: 127903-20-2
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Ammonium chloride-d4
0 ImagesCat. No.: HY-Y1269ASCAS No.: 12015-14-4Ammonium chloride-d4 is the deuterium labeled Ammonium chloride. Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor.
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SirReal2 (Standard)
0 ImagesSirReal2 (Standard) is the analytical standard of SirReal2 (HY-100591). This product is intended for research and analytical applications. SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration.
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Fasudil Hydrochloride (Standard)
0 ImagesSynonyms: HA-1077 Hydrochloride (Standard); AT-877 Hydrochloride (Standard)Fasudil (Hydrochloride) (Standard) is the analytical standard of Fasudil (Hydrochloride). This product is intended for research and analytical applications. Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
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N-Methylpropane-1,3-diamine
0 ImagesCat. No.: HY-W010634CAS No.: 6291-84-5
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Entrectinib (Standard)
0 ImagesSynonyms: NMS-E628 (Standard); RXDX-101 (Standard)Entrectinib (Standard) is the analytical standard of Entrectinib. This product is intended for research and analytical applications. Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.
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Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)
0 ImagesCat. No.: HY-P990791Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71+ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft.
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Ethyl 2-(trans-4-aminocyclohexyl)acetate
0 ImagesCat. No.: HY-78596CAS No.: 76308-28-6
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YH239-EE
0 ImagesYH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.
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1,15-Pentadecanediol
0 ImagesCat. No.: HY-W074868CAS No.: 14722-40-8
