Infection

Roselipin 2B inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.

IDX375 is a novel non-nucleoside inhibitor with selective inhibitory activity against HCV NS5B. IDX375 has good selectivity for genotypes 1a and 1b. The structure and binding site of IDX375 were confirmed by X-ray cocrystal studies.

Antimalarial agent 47 (compound F14) is an antimalarial compound, with an IC₅₀ of 235 nM for the Plasmodium falciparum W2 strain.

Maridomycin VI is a macrolide antibiotic. Maridomycin VI has the activity against Gram-positive bacteria and mycoplasma. Maridomycin VI has the effect of protecting Gram-positive bacterial infection mice.

Antibacterial agent 329 (Compound 9c) is an antibacterial agent. Antibacterial agent 329 inhibits the activity of MraY. Antibacterial agent 329 exhibits antibacterial activity against Escherichia coli K12 and Bacillus subtilis W23 with a MIC of 16 μg/mL, but shows no activity against Pseudomonas fluorescens Pf-5. Antibacterial agent 329 exerts antibacterial activity against Acinetobacter baumannii 19606, Staphylococcus aureus MRSA USA300 JE2, Enterobacter cloacae 19434, Klebsiella pneumoniae 700603 and Enterococcus faecium 19434, with MIC values of 8, 8, 16-32, 16-32 and 16 μg/mL, respectively, while it shows no activity against Pseudomonas aeruginosa NCTC 13437.

PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC₅₀ of 17.4 nM. PAN endonuclease-IN-3 demonstrates potent inhibitory activities against PAN endonuclease. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model.

BFC220 is a covalent SARS-CoV-2 Mpro inhibitor with an IC₅₀ of 2.77 μM. BFC220 can be used for antiviral research.

Usaramine (Standard) is the analytical standard of Usaramine. This product is intended for research and analytical applications. Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria.

Tecnazene (Standard) is the analytical standard of Tecnazene. This product is intended for research and analytical applications. Tecnazene is a dinitroaromatic fungicide and plant growth regulator. Tecnazene binds irreversibly to human skin tissues and exhibits acute toxicity in Rattus norvegicus (brown rat). Tecnazene exerts sprouting-inhibiting and antifungal activities by inhibiting the sprouting of potato tuber buds and blocking the growth and reproduction of fungi that cause dry rot. Tecnazene has significant antifungal and sprouting-inhibiting activities, and shows high toxicity to aquatic organisms such as freshwater fish and crustaceans. Tecnazene is used for sprouting inhibition and dry rot control during potato storage.

Tetromycin A is a tetronic acid-based antibiotic. It reportedly has pronounced activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Related tetromycin derivatives have been found to have anti-trypanosomal activity and inhibit the cysteine protease cathepsin L with Ki values in the low micromolar range.

Ezomycin D2 is an antifungal antibiotic. Ezomycin D2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.

Carpetimycin B has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin B has a strong inhibitory effect on β-lactamase.

Furalaxyl (Standard) is the analytical standard of Furalaxyl. This product is intended for research and analytical applications. Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.

Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum.

Cilastatin (Standard) is the analytical standard of Cilastatin. This product is intended for research and analytical applications. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin is an antibacterial adjunct.

2'-Deoxyuridine-1′-¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A).

N3-C5-O-C-Boc is a linker, which can be utilized for the synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789).

Swietemahalactone is a natural compound isolated from Swietenia mahagoni. Swietemahalactone exhibits antibacterial activity aganist E. coli.

2-Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC₅₀=39.6 μM). 2-Methylcardol triene is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM. 2-Methylcardol triene has been used as a starting material for the synthesis of mono- and bis-benzoxazines.