Infection

BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability.

BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward HIV-1 reverse transcriptase (RT). BILR 355 can be used for HIV infections research.

FK-041 is an orally active cephalosporin antibiotic with high affinity for penicillin-binding proteins (PBPs). FK-041 exhibits broad-spectrum antibacterial activity, exerting potent antibacterial effects against Gram-positive bacteria, most Gram-negative bacteria, anaerobes, and so on. FK-041 also shows good efficacy against some drug-resistant strains such as penicillin-resistant Streptococcus pneumoniae. FK-041 is an antibacterial agent and can be used in the research of infectious diseases.

DRAMP18563 (MAP-04-02) is a linear antimicrobial peptide that can act as a delivery vector to transport dual-ring peptide inhibitors that cannot penetrate the outer membrane of Gram-negative bacteria to their target sites. DRAMP18563 can be used to study the delivery strategies of dual-ring peptide inhibitors.

Myeloperoxidase, Human Neutrophil is a peroxidase. Myeloperoxidase, Human Neutrophil is a potent antibacterial agent by catalyzing the H₂O₂-dependent oxidation of chloride anion to generate hypochlorous acid. Myeloperoxidase, Human Neutrophil catalyzes the degradation of N-retinyl-idene-N-retinylethanolamine, a toxic form of retinal lipofuscin. Myeloperoxidase, Human Neutrophil also triggers lysosomal stress and cell death. Myeloperoxidase, Human Neutrophil can be used for the researches of inflammation and infection.

Brevinin-1E is an antimicrobial peptide derived from the skin secretions of Rana esculenta.

SARS-CoV-2 Mpro-IN-12 (compound D026) is a SARS-CoV-2 main protease (Mpro) inhibitor with antiviral activities.

HCV-IN-35 (Compound (R)-3h) is a potent inhibitor of HCV. HCV-IN-35 has the potential for the research infection diseases.

Anti-MRSA agent 2 (compound 14) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and relatively low cytotoxicity in normal cells. Anti-MRSA agent 2 has strong ability to destroy bacterial membrane and bind to genomic DNA.

Sofosbuvir-¹³C,d₃ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

Ciprofloxacin lactate solution is mainly composed of Ciprofloxacin lactate (HY-W040298). Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7.

Saquinavir-d₉ (Ro 31-8959-d₉) is the deuterium labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.

LEX-SQ01 (Compound D10) is an antifungal agent. LEX-SQ01 shows an EC₅₀ of 1.6 μM for C. capsici. LEX-SQ01 can disrupt the cell membrane integrity of fungal. LEX-SQ01 can be used for the research of infection in crops.

AMPR-22 is an antimicrobial peptide. AMPR-22 can bind to the bacterial membrane and induces membrane permeabilization. AMPR-22 is effective against murine model of sepsis induced by MDR strains

Amoxicillin (sodium) (Standard) is the analytical standard of Amoxicillin (sodium). This product is intended for research and analytical applications. Amoxicillin (Amoxycillin) sodium is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin sodium inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].

SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM^>[1].

CRAMP (1-39) is an antimicrobial peptide. CRAMP (1-39) has shown potent bactericidal effects against multiple strains of Neisseria meningitidis in vitro. CRAMP (1-39) can be used to study drug-resistant bacterial infections.

Furaprevir is a potent and selective HCV NS3/4A protease inhibitor. Furaprevir can be used for genotype 1 hepatitis C research.

LASSBio-1736 is a Cysteine protease inhibitor and antimalarial agent. LASSBio-1736 targets the promastigote form of Leishmania major. LASSBio-1736 can be used in the research of leishmaniasis.