2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N19689
    4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate 549503-17-5 98%
    4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate is a plant secondary metabolite that can be found in the leaves of Moringa oleifera and Moringa stenopetala. 4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate can be used for research on cancer and inflammatory diseases.
    4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate
  • HY-N19714
    Aspacochinoside N 1494664-27-5 98%
    Aspacochinoside N is a pregnane glycoside (steroidal saponin) found in the roots of Asparagus cochinchinensis with an IC50 > 100 μM for NO production inhibition. Aspacochinoside N can be used in research on neuroinflammation.
    Aspacochinoside N
  • HY-N19715
    Asperosaponin H1 159993-47-2 98%
    Asperosaponin H1 is a triterpenoid saponin (octasaccharide saponin) found in the roots of Dipsacus asperoides C.Y. Cheng et T.M. Ai. Asperosaponin H1 can be used for research on liver and kidney diseases.
    Asperosaponin H1
  • HY-N19717
    Bartogenic acid 79355-89-8 98%
    Bartogenic acid is an orally active NF-κB inhibitor, found in Barringtonia racemosa fruits. Bartogenic acid increases catalase, superoxide dismutase (SOD), and glutathione levels. Bartogenic acid inhibits lipid peroxidation and suppresses inflammation markers. Bartogenic acid can be used for the research of ovarian cancer, skin cancer, and inflammatory conditions.
    Bartogenic acid
  • HY-N19719
    Bispyrayafoline 1715114-37-6 98%
    Bispyrayafoline is a pyrrolidone and antioxidant with an IC50 value of 13.85 μM against DPPH. Bispyrayafoline can be found in the leaves of Murraya koenigii (Linn.) Spreng. Bispyrayafoline's antioxidant activity is concentration-dependent but time-independent. Bispyrayafoline can be utilized in studies concerning oxidative damage.
    Bispyrayafoline
  • HY-N19723
    Buddlejasaponin I 139501-36-3
    Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE2, TXB2, and the 5-LOX metabolite LTC4. Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research.
    Buddlejasaponin I
  • HY-N19801
    N-Palmitoyl-D-glucosamine 54627-18-8 98%
    N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds MD-2 with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy.
    N-Palmitoyl-D-glucosamine
  • HY-N19807
    Dodec-2E-ene-8,10-diynoic acid isobutylamide 120727-29-9
    Dodec-2E-ene-8,10-diynoic acid isobutylamide is an alkamide found in Echinacea angustifolia that binds to CB1 (rat Ki = 61.1 μM) and CB2 (mouse Ki = 47.2 μM) cannabinoid receptors. Dodec-2E-ene-8,10-diynoic acid isobutylamide can be used in research on inflammatory diseases.
    Dodec-2E-ene-8,10-diynoic acid isobutylamide
  • HY-N19816
    7-O-Methyl glabranin 75291-75-7 98%
    7-O-Methyl glabranin is a flavonoid compound and also an inhibitor of LPS-induced TNF-α and IL-1β production. 7-O-Methyl glabranin can be used in the research of diseases such as inflammation.
    7-O-Methyl glabranin
  • HY-N19827
    Monodesmoside saponin C 84607-60-3 98%
    Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca2+. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca2+ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics.
    Monodesmoside saponin C
  • HY-N19847
    LYRM03 1820750-36-4
    LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer.
    LYRM03
  • HY-N1984R
    Artemisic acid (Standard) 80286-58-4
    Artemisic acid (Standard) (Qing Hao acid (Standard)) is the analytical standard of Artemisic acid (HY-N1984). This product is intended for research and analytical applications. Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect.
    Artemisic acid (Standard)
  • HY-N1986R
    Cucurbitacin D (Standard) 3877-86-9
    Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects.
    Cucurbitacin D (Standard)
  • HY-N19870
    Verbascosaponin 141896-30-2 98%
    Verbascosaponin (Ilwensisaponin A) is an orally active oleanane-triterpene saikosaponin found in crophularia auriculata ssp. pseudoauriculata. Verbascosaponin can be used for the research of inflammation.
    Verbascosaponin
  • HY-N19876
    WF-5239 91224-36-1
    WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis.
    WF-5239
  • HY-N19877
    Neokadsuranic acid B 123828-59-1 98%
    Neokadsuranic acid B is a 14 (13→12)-seco-lanostane-type triterpenoid acid that exists in the stems of Kadsura longipedunculata and Radix Aconiti Lateralis Preparata. It has high binding affinity for PTGS2 (COX-2). Neokadsuranic acid B shows promise for research into rheumatoid arthritis.
    Neokadsuranic acid B
  • HY-N1987R
    Cucurbitacin IIb (Standard) 50298-90-3
    Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α.
    Cucurbitacin IIb (Standard)
  • HY-N1988R
    Cucurbitacin IIa (Standard) 58546-34-2
    Cucurbitacin IIa (Hemslecin A) (Standard) is the analytical standard for Cucurbitacin IIa (HY-N1988). This product is used for research and analytical applications. Cucurbitacin IIa is an orally active, blood-brain barrier-penetrating EGFR inhibitor with an IC50 of 1.455 nM for human EGFR. Cucurbitacin IIa induces caspase-3 dependent cell apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton through actin aggregation, blocks the cell cycle at the G2/M phase, and inhibits the EGFR-MAPK signaling pathway to exert anti-inflammatory activity. Cucurbitacin IIa can be used in research on inflammatory-related diseases, depression, and non-small cell lung cancer and other cancers.
    Cucurbitacin IIa (Standard)
  • HY-N1990R
    Gypenoside XLIX (Standard) 94987-08-3
    Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells.
    Gypenoside XLIX (Standard)
  • HY-N2007S
    Veratric acid-d6 1162658-12-9 98%
    Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
    Veratric acid-d6
Cat. No. Product Name / Synonyms Application Reactivity