Metabolic Disease

Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action.

Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC₅₀ of 26.6 μM.

C18(Plasm)-18:1 PE is a lycerophospholipid.

Linolenyl palmitate is an ester product.

Iron Sucrose solution is mainly composed of Iron sucrose (HY-B2068). Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment.

Asimadoline hydrochloride (Standard) (EMD-61753 hydrochloride (Standard)) is the analytical standard of Asimadoline (hydrochloride) (HY-107384A). This product is intended for research and analytical applications. Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC₅₀s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS).

DMTr-2'-O-propyl-rG(iBu)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.

1,3-Dipentanoin is a glycerolipid.

AL-4114 is an aldose reductase inhibitor which can be utilized in research related to the prevention of diabetic cataractogenesis.

(±)6,7-DiHODE(γ), a oxylipin, is a dihydroxyoctadecadienoic acid.

Methyl 3-hydroxyoctadecanoate is an ester product.

G6PDi-1 (Standard) is the analytical standard of G6PDi-1 (HY-W107464). This product is intended for research and analytical applications. G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀ of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytoK_ine production in T cells.

KHK-IN-8 is a selective KHK inhibitor, with an IC₅₀ of 13.0 nM against hKHK-C and an IC₅₀ of 22.7 nM against hKHK-A. KHK-IN-8 is applicable to research on non-alcoholic steatohepatitis, type 2 diabetes and obesity.

2'-Deoxy-3',5'-ADP (pdAp) is a monomeric raw material that can be used for nucleic acid synthesis.

1-Olein-3-butyrin is an acylglycerol.

Ethyl 11(Z)-octadecenoate is an ester product.

Myristelaidic acid (trans-9-Tetradecenoic acid) sodium, a 14-carbon trans fatty acid, is the trans isomer of Myristoleic acid. Myristelaidic acid is found in most animal fats.

LY456236 (Standard) is the analytical standard of LY456236 (HY-103566). This product is intended for research and analytical applications. LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC₅₀ of 0.145 μM. LY456236 can also inhibit EGFR, with an IC₅₀ of 0.918 μM. LY456236 has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research.

Lignoceryl lignocerate is an ester product.

ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC₅₀ value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes.