Neurological Disease

L-Methionine-DL-sulfoximine (Standard) is the analytical standard of L-Methionine-DL-sulfoximine (HY-B1692). This product is intended for research and analytical applications. L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS).

Norgestrel-d₅ is deuterium-labeled Norgestrel (HY-N7137).

H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC₅₀ of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders.

PSB-12062 (Standard) is the analytical standard of PSB-12062 (HY-101910). This product is intended for research and analytical applications. PSB-12062 is a potent and selective P2X4 antagonist with an IC₅₀ of 1.38 μM for human P2X4.

Cannabinol acetate (Acetylcannabinol) is structurally similar to known phytocannabinoids.

Methiothepin (mesylate) (Standard) is the analytical standard of Methiothepin (mesylate). This product is intended for research and analytical applications. Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).

Sepimostat (Standard) is the analytical standard of Sepimostat. This product is intended for research and analytical applications. Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 μM.

Mouse Pou3f2 mRNA encodes the mouse POU domain, class 3, transcription factor 2 (Pou3f2) protein, a transcription factor that plays a key role in neuronal differentiation.

TMI-1 (Standard) is the analytical standard of TMI-1 (HY-101448). This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions.

Zalospirone (WY-47846) is a novel cyclic imide with 5-HT1A partial agonist activity. Zalospirone shows antidepressant efficacy.

NAN-190 (hydrobromide) (Standard) is the analytical standard of NAN-190 (hydrobromide). This product is intended for research and analytical applications. NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.

WAY-100635 (Standard) is the analytical standard of WAY-100635. This product is intended for research and analytical applications. WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist.

(Rac)-NMDAR antagonist 1 (Standard) is the analytical standard of (Rac)-NMDAR antagonist 1 (HY-111500). This product is intended for research and analytical applications. (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.

AS057278 (Standard) is the analytical standard of AS057278. This product is intended for research and analytical applications. AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia.

SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC₅₀ 7 and 37 μM, respectively.

Dexrazoxane (Standard) is the analytical standard of Dexrazoxane. This product is intended for research and analytical applications. Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .

Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression.

Vanillyl alcohol (Standard) is the analytical standard of Vanillyl alcohol (HY-N2067). This product is intended for research and analytical applications. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases Bcl-2. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages.

1-(3-Chloro-4-fluorophenyl)piperazine hydrochloride is a piperazine.

Purmorphamine (Standard) is the analytical standard of Purmorphamine (HY-15108). This product is intended for research and analytical applications. Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM.