Cyprolidol
Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 4904-00-1
- 分子式: C21H19NO
- 分子量:301.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Histamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体内実験
Cyprolidol (10 mg/kg; i.v.; single dose) produces a mean -34.16 mmHg systolic pressure fall in anesthetized dogs, while also potentiating norepinephrine and epinephrine pressor responses and inhibiting tyramine, histamine, acetylcholine, and serotonin responses[1].
Cyprolidol (10-30 mg/kg; i.v.; single dose) produces a biphasic systolic pressure response (-34.00 mmHg fall followed by +38.00 mmHg rise) in anesthetized cats, while also potentiating norepinephrine and epinephrine pressor responses, inhibiting tyramine, histamine, acetylcholine, serotonin, and bretylium responses, and at 30 mg/kg i.v. reversing bretylium-induced pressure rises to falls[1].
Cyprolidol (30 mg/kg; p.o.; daily; 14 days) does not alter normotensive systolic pressure in conscious dogs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 4904-00-1
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分子量 301.38
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分子式 C21H19NO
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3[C@H](C4=CC=NC=C4)C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Protocol for Tail Suspension Test (TST)
The Tail Suspension Test is a mouse behavioral assay in which an animal is suspended by the tail in an inescapable position, causing alternating escape-directed activity and immobility; the main readout is immobility time, and antidepressant-like treatments generally reduce immobility compared with vehicle controls. The assay detects behavioral response to acute inescapable stress rather than a molecular event; immobility is interpreted as passive stress-coping behavior, while reduced immobility is used as a predictive screen for antidepressant-like activity, with important limitations related to strain, locomotor activity, and tail-climbing behavior.
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Protocol for Forced Swim Test (FST)
The Forced Swim Test is a rodent behavioral assay in which a mouse or rat is placed in an inescapable cylinder of water, and the main readout is the time spent immobile versus active escape-related behaviors such as swimming or climbing. Reduced immobility after treatment has historically been interpreted as antidepressant-like activity, but the assay should be interpreted as a behavioral response to acute inescapable stress rather than a complete model of human depression.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cyprolidol 関連分類
HY-184374 関連分類
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