Neurological Disease

Maropitant (Standard) is the analytical standard of Maropitant. This product is intended for research and analytical applications. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

AMN082 (Standard) is the analytical standard of AMN082. This product is intended for research and analytical applications. AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.

NS1652 (Standard) is the analytical standard of NS1652 (HY-100244). This product is intended for research and analytical applications. NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.

Tasipimidine sulfate (Standard) is the analytical standard of Tasipimidine (sulfate) (HY-109075A). This product is intended for research and analytical applications. Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC₅₀ of 7.57 for human α2A-adrenoceptors and an EC₅₀ of 5.7 nM for rat α2-adrenoceptor. Tasipimidine sulfate can be utilized in research related to situational anxiety and fear.

S-Methyl-L-cysteine (Standard) is the analytical standard of S-Methyl-L-cysteine. This product is intended for research and analytical applications. S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

Fluvoxamine-¹³C, d₃ maleate is ¹³C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

3-Chloroamphetamine hydrochloride is a derivative of Amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.

1-(2-Trifluoromethylphenyl)piperazine hydrochloride is a piperazine.

Enecadin (Standard) is the analytical standard of Enecadin (HY-100119). This product is intended for research and analytical applications. Enecadin is a neuroprotective agent extracted from patent US 8623823 B2.

N-Acetylcysteine amide (Standard) is the analytical standard of N-Acetylcysteine amide (HY-110256). This product is intended for research and analytical applications. N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent, reduces ROS production.

5-Fluoro PB-22 8-hydroxyisoquinoline isomer is structurally similar to known synthetic cannabinoids.

DD-161515 is a TRPV1/VR1 inhibitor with an IC₅₀ of 0.7 μM in rats. DD-161515 binds to an allosteric site of TRPV1 distinct from that of capsaicin, blocks channel opening, inhibits receptor-mediated calcium ion influx, reduces the excitability of peripheral sensory nerve fibers, and thereby inhibits nociception induced by heat and transmission of chemically induced pain signals. DD-161515 can be used in studies related to inflammatory pain.

SC-53116 is a selective 5-HT4 receptor agonist with EC₅₀ at 23 nM.

Desfesoterodine (Standard) is the analytical standard of Desfesoterodine. This product is intended for research and analytical applications. Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.

PD-89211 is a selective dopamine D4 receptor antagonist with a K_i value of 3.7 nM. PD-89211 reverses Quinpirole (HY-B1752A)-induced [3H]thymidine uptake in CHOpro5 cells (IC₅₀ = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia.

Saponarin (Standard) is the analytical standard of Saponarin (HY-N5083). This product is intended for research and analytical applications. Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders.

NSC 15364 (Standard) is the analytical standard of NSC 15364 (HY-108937). This product is intended for research and analytical applications. NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.

Cloroperone is a 5-HT₂ receptor inhibitor with a K_i value of 4.5 nM. Cloroperone can be used in research on psychiatric disorders.

QX-222 (chloride) (Standard) is the analytical standard of QX-222 (chloride) (HY-101362). This product is intended for research and analytical applications. QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker.

Rimcazole dihydrochloride (Standard) is the analytical standard of Rimcazole (dihydrochloride) (HY-108510). This product is intended for research and analytical applications. Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.