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Ropidoxuridine (Synonyms: IPdR)

Cat. No.: HY-13742
Handling Instructions

Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.

For research use only. We do not sell to patients.

Ropidoxuridine Chemical Structure

Ropidoxuridine Chemical Structure

CAS No. : 93265-81-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.

In Vitro

Ropidoxuridine is an orally bioavailable pro-drug of IUdR (5-iodo-2'-deoxyuridine). Ropidoxuridine demonstrates strong synergy effects with Alisertib at clinically relevant concentrations[1].

In Vivo

In an orthotopic tumor model, Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) demonstrate strong synergy effects[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9577 mL 14.7885 mL 29.5770 mL
5 mM 0.5915 mL 2.9577 mL 5.9154 mL
10 mM 0.2958 mL 1.4789 mL 2.9577 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

338.10

Formula

C₉H₁₁IN₂O₄

CAS No.

93265-81-7

SMILES

O=C1N=CC(I)=CN1[[email protected]]2C[[email protected]](O)[[email protected]@H](CO)O2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ropidoxuridine
Cat. No.:
HY-13742
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Ropidoxuridine

Cat. No.: HY-13742