1. MAPK/ERK Pathway
  2. Ribosomal S6 Kinase (RSK)

SL 0101-1 (Synonyms: SL0101)

Cat. No.: HY-15237
Handling Instructions

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase.

For research use only. We do not sell to patients.

SL 0101-1 Chemical Structure

SL 0101-1 Chemical Structure

CAS No. : 77307-50-7

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  • Biological Activity

  • Technical Information

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  • References

Description

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].

IC50 & Target

IC50: 89 nM (RSK)[1].

References
Molecular Weight

516.45

Formula

C₂₅H₂₄O₁₂

CAS No.

77307-50-7

SMILES

OC1=CC(O)=C(C(C(O[[email protected]@H]2O[[email protected]@H](C)[[email protected]](OC(C)=O)[[email protected]@H](OC(C)=O)[[email protected]]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SL 0101-1
Cat. No.:
HY-15237
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SL 0101-1

Cat. No.: HY-15237