5-HT Receptor Agonist

5-HT2A agonist-12 is a human 5-HT2A receptor agonist with an EC₅₀ of 0.78 μM (in Chinese hamster ovary cells). 5-HT2A agonist-12 modulates intracellular calcium mobilization in cells expressing the human 5-HT2A receptor. 5-HT2A agonist-12 can be used in research related to depression.

5-HT2 agonist-1 (Compound 24) free base is a 5-HT2A & 5-HT2B & 5-HT2C agonist, with IC₅₀s of 10 nM, 8.3, and 1.6 nM respectively. 5-HT2 agonist-1 free base can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders.

BMS-181885 is a selective 5-HT₁ receptor agonist and a ligand for 5-HT_1B/_1D receptors. BMS-181885 exhibits anti-migraine activity. BMS-181885 can be used in the research of neurological diseases such as migraine.

Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.

Lesopitron hydrochloride is a 5-HT receptor agonist with potent anxiolytic-like effects. Lesopitron hydrochloride inhibits forskolin-stimulated adenylate cyclase activity with an IC₅₀ value of 125 nM.

PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

S(-)-8-OH-DPAT (S(-)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is an enantiomer of 8-OH-DPAT hydrobromide. 8-OH-DPAT hydrobromide is a potent, selective 5-HT_1A agonist with a pIC₅₀ of 8.19.

5-HT2C agonist-13 is an orally active, selective and brain-penetrant 5-HT_2C receptor agonist with human 5-HT_2C receptor EC₅₀ of 16 nM, K_i of 20 nM. 5-HT2C agonist-13 functionally activates 5-HT_2C receptors, reduces food intake, reduces body weight gain, and exhibits effects reversible by a selective 5-HT_2C antagonist. 5-HT2C agonist-13 can be used for the research of obesity.

Almotriptan-d₆ (PNU180638-d₆) maleate is the deuterium labeled Almotriptan maleate. Almotriptan malate is an orally active, highly selective agonist of the 5-HT_1B/1D receptor (5-HT_1B/1D receptor), with EC₅₀ values of 1.6 nM and 3.1 nM, respectively. Almotriptan malate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan malate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan malate can be used in research related to migraine.

(S)-5-HT2CR agonist 1 (Compound (S)-16k) is selective 5-HT_2CR agonist, with an EC₅₀ of 14 nM. FXa-IN-2 can be used in the research of hyperlocomotion.

WAY 629 hydrochloride is a potent and selective 5-HT_2C agonist with EC₅₀s of 426, 260000 nM for 5-HT_2C and 5-HT_2A, respectively. WAY 629 hydrochloride decreases feeding behavior.

25B-NBF hydrochloride is a highly potent agonist for the 5-HT2C receptor binds human 5-HT2A receptors and rat 5-HT2C receptors with pK_i values of 8.57 and 7.73, respectively.

RS-64459-193 is a 5-HT1A receptor partial agonist with a K_i of 24.9 nM. RS-64459-193 also shows high affinity for 5-HT2C, 5-HT2A and 5-HT7 with pK_i values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is almost devoid of activity at the m 5-HT3 receptor.

TMPPAA is an allosteric agonist and positive allosteric modulator of the 5-HT3 receptor. TMPPAA enhances 5-HT-mediated 5-HT3AR signaling.

Buspirone (hydrochloride) (Standard) is the analytical standard of Buspirone (hydrochloride). This product is intended for research and analytical applications. Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.

Donitriptan Mesylate is a potent, high efficacy agonist at 5-HT_1B/1D receptors with pK_is of 9.4 and 9.3, respectively.

2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT maleate is shown to display anti-depressive-like effects.

F 13714 (F 14679) is a prototypical 5-HT_1A agonist with a pK_i of 10.23. F 13714 induces large Ca²⁺ responses.

RU 27849 (Compound 27) is a 5-HT receptor 2A agonist, and can be used to study tryptamine recognition site binding.

(Rac)-S 16924 is a partial agonist of the 5-HT1A receptor. (Rac)-S 16924 regulates signaling through its interaction with the 5-HT1A receptor, and (Rac)-S 16924 can stabilize the receptor in its G-protein-coupled conformation without fully activating it, which may affect intracellular signaling pathways associated with this receptor. (Rac)-S 16924 can be used to study the 5-HT1A receptor in mental disorders, especially schizophrenia.