Cholinesterase (ChE)
Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.
There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.
Cholinesterase (ChE) Isoform Specific Products
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Cholinesterase (ChE) Related Products (1068)
Related Products (1068)
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Antibodies (2)
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Cholinesterase (ChE) Isoform Comparison
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7β-Hydroxybufalin
0 ImagesCat. No.: HY-N6575CAS No.: 20143-97-97β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase.
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BuChE-IN-3
0 ImagesCat. No.: HY-146686CAS No.: 2499488-78-5BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE with an IC50 of 8.3 nM. BuChE-IN-3 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity.
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BChE-IN-3
0 ImagesCat. No.: HY-144689CAS No.: 3033413-58-7
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K203
0 ImagesCat. No.: HY-146959CAS No.: 955034-69-2K203 is a potent reactivator of tabun-inhibited AChE. K203 is a crucial antidote used for the organophosphate intoxication.
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Velnacrine-d3 maleate
0 ImagesCat. No.: HY-W011246SSynonyms: HP 029-d3-1; Hydroxytacrine-d3-1 maleateVelnacrine-d3-1 maleate (HP 029-d3-1) is the deuterium labeled Velnacrine maleate (HY-W011246). Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
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Echimidine N-oxide
0 ImagesCat. No.: HY-N9513CAS No.: 41093-89-4Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
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Dihydroconiferyl dihydro-p-coumarate
0 ImagesCat. No.: HY-N21789CAS No.: 152543-09-4Dihydroconiferyl dihydro-p-coumarate is a mesophenolic acetylcholinesterase (AChE) inhibitor discovered in orchids such as Vanda roxburghii and Dendrobium nobile, with an IC50 of 118.17 μg/mL against mouse AChE. Dihydroconiferyl dihydro-p-coumarate reduces the hydrolytic activity of AChE, scavenges DPPH and hydroxyl radicals, exhibits potassium ferricyanide reducing power, reduces Mo (VI) to Mo (V), and inhibits lipid peroxidation in mouse brain homogenates. Dihydroconiferyl dihydro-p-coumarate is a key hypoglycemic compound and shows no significant cytotoxicity to human cancer cells. Dihydroconiferyl dihydro-p-coumarate can be used in research related to Alzheimer's disease and type 2 diabetes.
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AChE/BChE-IN-30
0 ImagesCat. No.: HY-175973AChE/BChE-IN-30 (Compound 3g) is a Cholinesterase dual-target competitive inhibitor. AChE/BChE-IN-30 can inhibit AChE and BChE with IC50 values of 0.338 and 2.087 μM and Ki values of 0.045 and 0.789 μM. AChE/BChE-IN-30 can be used for the research of neurological disease, such as Alzheimer's disease.
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ChEs/MAOs-IN-2
0 ImagesCat. No.: HY-158092CAS No.: 693268-77-8ChEs/MAOs-IN-2 (compound a11) is a cholinesterases and monoamine oxidases inhibitor with IC50 values of 0.10, 0.20, 0.30, 0.40 µM for MAO-A, MAO-B, AChE, and BChE, respectively. ChEs/MAOs-IN-2 has the potential for the research of Alzheimer's disease.
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BChE-IN-51
0 ImagesCat. No.: HY-184664CAS No.: 3131794-81-2BChE-IN-51 is a selective, blood-brain barrier-permeable, orally active BChE inhibitor with an IC50 of 0.03 μM against hBChE. BChE-IN-51 reduces ROS production, protects neurons from the toxic effects of hydrogen peroxide and Aβ1-42, and alleviates cognitive impairment. BChE-IN-51 can be used for the research of Alzheimer's disease.
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Huperzine C
0 ImagesCat. No.: HY-122957CAS No.: 163089-71-2Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC50 of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease.
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JDS364
0 ImagesCat. No.: HY-184279CAS No.: 2072857-15-7JDS364 is a blood-brain barrier-permeable human acetylcholinesterase (hAChE) reactivator with an IC50 of 8.6 μM. JDS364 achieves rapid systemic exposure in mice and acts as a protective agent when used in combination with Atropine (HY-B1205). JDS364 can be used in studies on organophosphate nerve agent poisoning and organophosphate pesticide poisoning.
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Asoxime dimesylate
0 ImagesCat. No.: HY-106901BCAS No.: 144252-71-1Synonyms: HI-6 dimesylateAsoxime dimesylate (HI-6 dimesylate) is an orally active thiosemicarbazone-based antidote. Asoxime dimesylate is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dimesylate significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dimesylate is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dimesylate can serve as an effective immunomodulator, improving the immune effect of the nervous system.
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Isogarcinol
0 ImagesCat. No.: HY-127087CAS No.: 71117-97-0Synonyms: Cambogin
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BChE-IN-36
0 ImagesCat. No.: HY-169163hBChE-IN-4 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. hBChE-IN-4 shows no cytotoxicity. hBChE-IN-4 shows potent procognitive effects. hBChE-IN-4 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders.
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Galanthamine-d3 hydrobromide
0 ImagesCat. No.: HY-A0009SSynonyms: Galantamine-d3 hydrobromideGalanthamine-d3 (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).
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Scutellarein 4'-methyl ether 7-O-glucuronide
0 ImagesCat. No.: HY-N17775CAS No.: 64924-06-7Synonyms: ClerodendrosideScutellarein 4'-methyl ether 7-O-glucuronide (Clerodendroside) is a flavonoid inhibitor of acetylcholinesterase (AChE) (IC50=1 mg/mL). Scutellarein 4'-methyl ether 7-O-glucuronide can be isolated from Plectranthus barbatus. It also possesses antioxidant activity and can be used in research on neurological diseases such as Alzheimer's disease.
