Aldose Reductase Inhibitor
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Mumeose K
0 ImagesCat. No.: HY-N13759CAS No.: 2132384-01-9Mumeose K is the inhibitor for aldose reductase with an IC50 of 27 μM. Mumeose K exhibits potential anti-diabetic activity, and can be used in research about diabetes-related complication.
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AKR1B1/STAT3/SLC7A11-regulator-1
0 ImagesCat. No.: HY-176719CAS No.: 2632263-80-8AKR1B1/STAT3/SLC7A11-regulator-1 (5a) is an AKR1B1/STAT3/SLC7A11 regulator that reverses DOX resistance in MCF-7/ADR cells by enhancing ferroptosis activity. AKR1B1/STAT3/SLC7A11-regulator-1 can be used in breast cancer research.
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Asperaldin
0 ImagesCat. No.: HY-N14186CAS No.: 561297-46-9Asperaldin is a potent aldose reductase (RLAR) inhibitor found in Aspergillus niger CFR-1046.
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Adhumulone
0 ImagesCat. No.: HY-N21682CAS No.: 31769-65-0Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC50 values of 5.41-29.27 μM and Ki values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies.
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ALR2-IN-8
0 ImagesCat. No.: HY-175639ALR2-IN-8 is a potent aldose reductase (ALR2/AKR1B1) inhibitor with a KI of 7.34 nM. ALR2-IN-8 has extremely low toxicity to normal cells and has a weak direct killing effect on cancer cells. ALR2-IN-8 can used for the studies of diabetic and inflammation-linked disorders.
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PTP1B/AKR1B1-IN-1
0 ImagesCat. No.: HY-149254PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC50 value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels.
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IDD388
0 ImagesIDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC50 of 14 μM).
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ALR2-IN-3
0 ImagesCat. No.: HY-151947CAS No.: 3062622-02-7ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC50s of 22 nM and 116 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications.
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APPA
0 ImagesCat. No.: HY-131542CAS No.: 100750-39-8APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin (HY-13753)-induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research.
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Minalrestat
0 ImagesCat. No.: HY-106877CAS No.: 129688-50-2Synonyms: ARI-509; WAY-ARI 509Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes.
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PTP1B/AKR1B1-IN-2
0 ImagesCat. No.: HY-149255PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM).
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ALR1/2-IN-1
0 ImagesCat. No.: HY-147977CAS No.: 2419233-57-9ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity.
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Methosorbinil
0 ImagesCat. No.: HY-W601605CAS No.: 102916-95-0Methosorbinil is an aldose reductase inhibitor with anti-cataract activity.
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Myrciacetin
0 ImagesCat. No.: HY-N9335CAS No.: 203734-35-4Myrciacetin is a flavonoid from Rhododendron dauricum. Myrciacetin is against rat lens aldose reductase with an IC50 of 13 μM.
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Dehydroglyasperin D
0 ImagesCat. No.: HY-N3716CAS No.: 517885-72-2Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi.
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ALR2-IN-7
0 ImagesALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (Ki=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers.
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Aldose reductase-IN-4
0 ImagesCat. No.: HY-146661CAS No.: 2446136-17-8Aldose reductase-IN-4 (compund IIc) is an aldose reductase inhibitor with IC50s of 11.70 μM and 0.98 μM for aldehyde reductase 1 (ALR1) and ALR2, respectively.
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Cemtirestat
0 ImagesCat. No.: HY-W151897CAS No.: 309283-89-4Synonyms: CMTICemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications.
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(Rac)-Ganoderic acid C2
0 ImagesCat. No.: HY-N1517ACAS No.: 98296-48-1(Rac)-Ganoderic acid C2 is the racemate of Ganoderic acid C2 (HY-N1517). Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses anti-tumor, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC50 of 3.8 µM[.
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Emodin-8-glucoside (Standard)
0 ImagesCat. No.: HY-N0311RCAS No.: 23313-21-5Emodin-8-glucoside (Standard) is the analytical standard of Emodin-8-glucoside. This product is intended for research and analytical applications. Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier.
