Aldose Reductase Inhibitor

Aldose reductase-IN-9 (Compound 8b) is an Aldose reductase (ALR2) inhibitor with a K_i value of 3.59 nM. Aldose reductase-IN-9 has anti-tumor activity.

ALR2-IN-10 (Compound 23) is a weak Aldose Reductase 2 inhibitor with inhibition rate of 6% at 27 μM. ALR2-IN-10 can be used for the research of diabetic complication.

Corybulbine, an alkaloid that can be isolated from the methanolic extract of Corydalis ternata, is an aldose reductase (ALR2) inhibitor. Corybulbine can be used for diabetic complications research.

AD-5467 is a potent and selective aldose reductase inhibitor. AD-5467 exhibits antidiabetic effect. AD-5467 can be used for the research of metabolic disease, such as diabetes.

AKR1C3-IN-17 is a cathepsin B (CTSB)-activated small molecule-drug conjugate targeting AKR1C3 with an IC₅₀ of 9 nM. AKR1C3-IN-17 is cleaved by CTSB to release the payload Gemcitabine (HY-17026). AKR1C3-IN-17 induces apoptosis and shows antitumor activity in mice. AKR1C3-IN-17 can be used for the study of hepatocellular carcinoma.

Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.

Salfredin A3 is an aldose reductase inhibitor.

Salfredin C2 is an aldose reductase inhibitor.

Salfredin C1 is an aldose reductase inhibitor.

Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside (HY-N4089). This product is intended for research and analytical applications. Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma.

ALR2-IN-9 is a potent ALR2 inhibitor (IC₅₀ = 21.8 nM) with excellent antioxidant activity (EC₅₀ for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO₄- and H₂O₂-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research.

SX 3202 is an aldose reductase inhibitor. SX 3202 can be used for the research of diabetic complications.

3,4,6-Tribromo-5-methylbenzene-1,2-diol (Compound 4) acts as an aldose reductase inhibitor with an IC₅₀ of 1.15 μg/mL. 3,4,6-Tribromo-5-methylbenzene-1,2-diol blocks the conversion of excessive D-glucose (HY-B0389) to D-sorbitol (HY-B0400) via the polyol pathway. 3,4,6-Tribromo-5-methylbenzene-1,2-diol can be used in studies related to diabetic complications.

Salfredin C3 is an aldose reductase inhibitor.

Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. Ganoderic acid Df potently inhibits aldose reductase, with an IC₅₀ of 22.8 ± 0.6 μM.

Salfredin A4 is an aldose reductase inhibitor.

Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba (HY-N0309). Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications.

Imirestat (Standard) is the analytical standard of Imirestat. This product is intended for research and analytical applications. Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

Floramanoside A is a flavonol glycoside that can be isolated from the flowers of Abelmouschus manihot. Floramanoside A has DPPH scavenging (IC₅₀: 10.1 μM) and aldose reductase inhibition activities (IC₅₀: 17.8 μM).