CaMK Inhibitor

Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II (CaMKII) inhibitor. By inhibiting the activity of CaMKII, Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases.

Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC₅₀ values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a K_i value of 590 µM.

Alisol B (Standard) is the analytical standard of Alisol B (HY-N0805A). This product is intended for research and analytical applications. Alisol B is a triterpene with diverse biological activities. Alisol B binds human soluble epoxide hydrolase (sEH) with a K_i of 5.97 μM and reduces sEH activity. Alisol B inhibits RANKL-induced JNK phosphorylation, NFATc1 and c-Fos expression, osteoclast formation, mature osteoclast pit-forming and actin ring activity, and SERCA pump activity. Alisol B induces calcium mobilization, CaMKK-AMPK-mTOR pathway activation, autophagic flux, autophagosome formation, G1 phase cell cycle arrest, endoplasmic reticulum stress, unfolded protein responses, and cancer cell apoptosis. Alisol B can be used for the research of hypercalcemia, osteoporosis, rheumatoid arthritis, periodontitis, acute kidney injury, and breast cancer.

A-484954 (Standard) is the analytical standard of A-484954 (HY-110096). This product is intended for research and analytical applications. A-484954 is a highly selective eukaryotic elongationfactor-2 K_inase(eEF2K) inhibitor, with an IC₅₀ of 280 nM.

Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588). Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents.

STO-609 (Standard) is the analytical standard of STO-609 (HY-19805). This product is intended for research and analytical applications. STO-609 is a selective and cell-permeable inhibitor of the Ca²⁺/calmodulin-dependent protein K_inase K_inase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein K_inase K_inase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.

KN-93 (Standard) is the analytical standard of KN-93 (HY-15465). This product is intended for research and analytical applications. KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent K_inase type II (CaMK_iI) with a K_i of 370 nM.

CaMKII-IN-4 is a pyrimidine-based ATP-competitive CaMKIIδ inhibitor with an enzymatic IC₅₀ of >20 μM.