Drug-Linker Conjugates for ADC
Drug-Linker Conjugates for Antibody Drug Conjugates (ADCs) comprise of an active cytotoxic drug and an appropriate linker. After linked to a monoclonal antibody, those conjugates can be used for making ADCs, which are targeted agents for cancer cells with high selectivity and cytotoxicity.
The drug units in drug-linker conjugates are cytotoxic agents (i.e. ADC cytotoxins or payloads) with antitumor activity and can be classified in DNA damaging agents and tubulin inhibitors. The most commonly used DNA damaging agents in ADCs are Duocarmycins, Pyrrolobenzodiazepines, Camptothecins and Daunorubicins/Doxorubicins, while the popular tubulin inhibitors are Auristatins and Maytansinoids. Besides, there are also many traditional cytotoxic agents can be used in ADCs.
ADC linkers currently undergoing clinical evaluation are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, and noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule.
Drug-Linker Conjugates for ADC Isoform Specific Products
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Drug-Linker Conjugates for ADC
(327)
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Auristatin
(45)
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Camptothecins
(33)
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Daunorubicins/
Doxorubicins (5)View all products
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Duocarmycins
(8)
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Maytansinoids
(19)
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Pyrrolobenzodiazepines
(5)
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Traditional Cytotoxic Agents
(31)
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Dual payloads
(5)
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Drug-Linker Conjugates for ADC Related Products (500)
Related Products (500)
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Drug-Linker Conjugates for ADC Isoform Comparison
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Aminocaproyl-Val-Cit-PABC-Exatecan
0 ImagesCat. No.: HY-171931CAS No.: 3029114-39-1Aminocaproyl-Val-Cit-PABC-Exatecan is a drug-linker conjugate for ADC, consiting of a cleavable linker (Aminocaproyl-Val-Cit-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Aminocaproyl-Val-Cit-PABC-Exatecan can be used for ADC molecues synthesis.
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Cys-mc-MMAE
0 ImagesCat. No.: HY-157284Purity: 99.85%Cys-mc-MMAE is a Drug-Linker Conjugates for ADC, and consists of Monomethyl auristatin E (HY-15162) and a linker. Cys-mc-MMAE can be used for synthesis of ADCs.
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LD-114
0 ImagesCat. No.: HY-186031CAS No.: 3039924-67-6LD-114 is an agent-linker conjugate that can be used to make an antibody agent conjugate (ADC).
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DBCO-PEG3-Glu-VC-PABC-MMAF
0 ImagesCat. No.: HY-131158CAS No.: 2253947-24-7DBCO-PEG3-Glu-VC-PABC-MMAF (compound s19b) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable DBCO-PEG3-Glu-VC-PABC. DBCO-PEG3-Glu-VC-PABC-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs).
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Cys-MC-GGFG-Dxd-d5
0 ImagesCat. No.: HY-176415SCys-MC-GGFG-Dxd-d5 is the deuterium labeled Cys-MC-GGFG-Dxd (HY-176415). Cys-MC-GGFG-Dxd is a conjugate of Cys and Deruxtecan (HY-13631E). Cys-MC-GGFG-Dxd is a linker-toxin building block in antibody-drug conjugates (ADCs) used to link antibody Cys residues to cytotoxic drugs. Cys-MC-GGFG-Dxd can be used in cancer research.
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TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride
0 ImagesCat. No.: HY-156691ATLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is a drug-linker conjugates for ADC>. TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is the hydrochloride form of TLR7/8 agonist 4 hydroxy-PEG6-acid. TLR7/8 agonist 4 hydroxy-PEG6-acid consists of TLR7/8 agonist 4 (HY-139017) and a non-cleavable linker Hydroxy-PEG6-acid (HY-133050), and can be used for synthesis of ADCs.
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Barzuxetan
0 ImagesCat. No.: HY-138269CAS No.: 157380-45-5Synonyms: CHX-A''-DTPA-NCSBarzuxetan can be used for cancer diseases research.
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VcMMAE (Standard)
0 ImagesSynonyms: MC-Val-Cit-PAB-MMAE (Standard); mc-vc-PAB-MMAE (Standard); Vedotin (Standard)VcMMAE (Standard) is the analytical standard of VcMMAE. This product is intended for research and analytical applications.
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Thailanstatin A cyclohexane diamine formic
0 ImagesCat. No.: HY-160899AThailanstatin A cyclohexane diamine formic is an analog of Spliceostatin (HY-16466). Thailanstatin A cyclohexane diamine formic inhibits proliferations of cells N87 (IC50 is 0.33 μM), BT474 (IC50 is 0.34 μM), MDA-MB-361-DYT2 (IC50 is 0.88 μM) and MDA-MB-468 (IC50 is 0.27 μM). Thailanstatin A cyclohexane diamine formic is used as a drug-linker conjugate for ADC molecule.
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Cys-MC-GGFG-Dxd-d5 TFA
0 ImagesCat. No.: HY-176415S1Synonyms: Cys-MC-GGFG-Dxd-d5 TFACys-MC-GGFG-Dxd-d5 TFA (Cys-MC-GGFG-Dxd-d5 TFA) is the deuterium labeled Cys-MC-GGFG-Dxd (HY-176415). Cys-MC-GGFG-Dxd-d5 TFA is a conjugate of Cys and Deruxtecan (HY-13631E). Cys-MC-GGFG-Dxd-d5 TFA is a linker-toxin building block in antibody-drug conjugates (ADCs) used to link antibody Cys residues to cytotoxic drugs. Cys-MC-GGFG-Dxd-d5 TFA can be used in cancer research.
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AcLysValCit-PABC-DMAE-SW-163D
0 ImagesCat. No.: HY-114325CAS No.: 2411007-69-5AcLysValCit-PABC-DMAE-SW-163D is a agent-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker.
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Vat-Cit-PAB-Monomethyl Dolastatin 10
0 ImagesCat. No.: HY-126492CAS No.: 1415329-13-3Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.
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MB-VC-MGBA
0 ImagesCat. No.: HY-136289CAS No.: 932744-62-2MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC.
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ST8155AA1
0 ImagesCat. No.: HY-112806CAS No.: 2247025-63-2ST8155AA1 is a part of antibody agent conjugates (ADCs) charged with HDAC inhibitor. ST8155AA1 induces α-tubulin, histone H3/H4 acetylation via direct enzymatic inhibition. ST8155AA1 recognizes and binds EGFR, undergoes internalization into EGFR-expressing tumor cells. ST8155AA1 inhibits cancer cell proliferation and exerts activity in mouse tumor models. ST8155AA1 can be used for the research of non-small cell lung cancer.
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HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM
0 ImagesCat. No.: HY-145663CAS No.: 2243689-64-5HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a agent-linker (peptide-cleavable) conjugate for ADC. DM indicates the maytansinoid moiety.
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Nitro-PDS-Tubulysin M
0 ImagesCat. No.: HY-128896CAS No.: 1941168-69-9Nitro-PDS-Tubulysin M is a synthetic ADC drug-linker conjugate composed of the tubulin polymerization inhibitor Tubulysin M (an ADC Cytotoxin) and Nitro-PDS (an ADC linker).
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Sulfo-PDBA-DM4
0 ImagesCat. No.: HY-128954CAS No.: 1461704-01-7Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.
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MC-Sq-Cit-PAB-Gefitinib
0 ImagesCat. No.: HY-128893CAS No.: 1941168-63-3MC-Sq-Cit-PAB-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using Gefitinib (an EGFR tyrosine kinase inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.
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Mal-VC-PAB-ABAEP-Azonafide
0 ImagesCat. No.: HY-126692CAS No.: 2259318-48-2Mal-VC-PAB-ABAEP-Azonafide is a agent-linker conjugate for ADC with with potent antitumor activity by using Azonafide (a cytotoxin), linked via the ADC linker Mal-VC-PAB.
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MC-Val-Cit-PAB-dimethylDNA31
0 ImagesMC-Val-Cit-PAB-dimethylDNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using dimethylDNA31, linked via the ADC linker MC-Val-Cit-PAB. DimethylDNA31 has effective bactericidal activity against persisters and stationary-phase S. aureus.
