Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2769)
Related Products (2769)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Antifungal agent 114
0 ImagesCat. No.: HY-169119Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes.
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2-Hydroxymethylclavam
0 ImagesCat. No.: HY-N15062CAS No.: 66036-39-32-Hydroxymethylclavam is a β-lactam antibiotic. 2-Hydroxymethylclavam has antifungal activity, especially for plant pathogenic fungi.
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Pulegone (Standard)
0 ImagesPulegone (Standard) is the analytical standard of Pulegone (HY-N1500). This product is intended for research and analytical applications. Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
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Neosordarin
0 ImagesCat. No.: HY-N14858CAS No.: 439665-94-8Neosordarin has antifungal activity and inhibits S. Cerevisia with the IC50 of 0.2~0.3 μg/mL.
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PF-1163B
0 ImagesCat. No.: HY-123474CAS No.: 258871-60-2PF-1163B is an antifungal antibiotic.
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2-Phenylphenol sodium
0 Images2-Phenylphenol sodium is a phenolic disinfectant and toxic agent with bactericidal, fungicidal and growth-inhibiting activities. 2-Phenylphenol sodium serves as a post-harvest agricultural fungicide and food preservative. At specific concentrations, 2-Phenylphenol sodium inhibits the growth of E. coli strains, while at high concentrations, 2-Phenylphenol sodium completely blocks their proliferation. 2-Phenylphenol sodium acts as a substrate for biocatalytic conversion, and is converted to 3-phenylcatechol by 2-hydroxybiphenyl 3-monooxygenase in recombinant E. coli. 2-Phenylphenol sodium also undergoes electrochemical oxidation in phosphate buffer solution.
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Antifungal agent 113
0 ImagesCat. No.: HY-164643CAS No.: 1373311-69-3Antifungal agent 113 (compound 9a) is a potent antifungal and antibacterial agent. Antifungal agent 113 shows good antibacterial activity against S. aureus and methicillin-resistant S. aureus.
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Anticancer agent 151
0 ImagesCat. No.: HY-155167CAS No.: 1227476-97-2Anticancer agent 151 (compound 6C) is an anticancer agent. Anticancer agent 151 exhibits excellent in vitro cytotoxic activity against MCF-7 cells with an IC50 value of 6.3 μM.
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Ascochitine
0 ImagesAscochitine, a polyketide-derived secondary metabolite, is a selective antifungal agent. Ascochitine exhibits broad-spectrum phytotoxicity and antimicrobial activities.
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CYP51-IN-7
0 ImagesCat. No.: HY-136757CAS No.: 1155361-05-9CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively.
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Kayahope
0 ImagesCat. No.: HY-121633CAS No.: 49828-25-3Kayahope is a fungal inhibitor.
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Isavuconazonium sulfate (Standard)
0 ImagesCat. No.: HY-100373RCAS No.: 946075-13-4Synonyms: BAL8557-002 (Standard)Isavuconazonium (sulfate) (Standard) is the analytical standard of Isavuconazonium (sulfate) (HY-100373). This product is intended for research and analytical applications. Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis.
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Lepiochlorin
0 ImagesCat. No.: HY-121395CAS No.: 71339-41-8Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination.
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Polyoxin L
0 ImagesCat. No.: HY-N14216CAS No.: 22976-90-5Polyoxin L is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
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Penthiopyrad (Standard)
0 ImagesCat. No.: HY-17520RCAS No.: 183675-82-3Synonyms: MTF-753 (Standard)Penthiopyrad (Standard) is the analytical standard of Penthiopyrad. This product is intended for research and analytical applications. Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass.
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Ravuconazole-d4
0 ImagesRavuconazole-d4 is the deuterium labeled Ravuconazole. Ravuconazole (BMS-207147) is an orally available triazoleantifungle agent that potently inhibits a wide range of fungi.
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Acremine I
0 ImagesCat. No.: HY-N8511CAS No.: 1110661-29-4Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew.
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Kalafungin
0 ImagesCat. No.: HY-105751CAS No.: 11048-15-0Synonyms: Kalamycin; U-19718Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
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Epoxiconazole (Standard)
0 ImagesEpoxiconazole (Standard) is the analytical standard of Epoxiconazole. This product is intended for research and analytical applications. Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
