Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Verwandte Produkte (2637)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (2349)

Art. -Nr.	Produktname	Wirkung	Reinheit	Chemical Structure

HY-161813

Antibacterial agent 229	Inhibitor
Antibacterial agent 229 (compound 8a) is a potent antibacterial agent. Antibacterial agent 229 shows antibacterial and antifungal abilities. Antibacterial agent 229 disrupts the integrity of the bacterial membrane, intercalates into DNA. Antibacterial agent 229 inhibits topoisomerase IV with an IC₅₀ value of 10.88 µM.

HY-175198

Cs-2d	Inhibitor
Cs-2d is a selective ceramide synthases Cer1 inhibitor. Cs-2d has potent inhibitory activity toward C. neoformans Cer1, while maintaining a low off-target effect on human hCerS1. Cs-2d has potent antifungal activity with the significant growth inhibition. Cs-2d can be used for invasive fungal infections research.

HY-178469

SDH-IN-35	Inhibitor
SDH-IN-35 (Compound A17) is a potent succinate dehydrogenase (SDH) inhibitor with antifungal activity (EC₅₀=11.9 μM). SDH-IN-35 is promising for research of agricultural fungicide.

HY-W741557

Griseofulvic Acid	Inhibitor
Griseofulvic acid is a metabolite of the antifungal Griseofulvin (HY-17583). It induces protein aggregation and tubulin polymerization in cell-free assays.

HY-111222

PD 113270	Inhibitor
PD 113270 (CL 1565-B) is an antitumor agent. PD 113270 exhibits inhibitory effects to yeasts.

HY-N14552

Quadrilineatin	Inhibitor
Quadrilineatin has antifungal and bacterial effects.

HY-173283

Antifungal agent 129	Inhibitor
Antifungal agent 129 (Compound 4g) is an inhibitor targeting Rhizoctonia solani, with an EC₅₀ value of 4.27 mg/L. It has a good control effect against rice sheath blight in in vitro and in vivo experiments. Preliminary exploration through scanning electron microscopy, molecular docking, enzyme activity determination, and cytotoxicity experiments has revealed that Antifungal agent 129 may exert its inhibitory activity by affecting the cell structure or physiological processes of Rhizoctonia solani. Antifungal agent 129 can be used in the research of plant diseases in the agricultural field, such as rice sheath blight, which are caused by Rhizoctonia solani.

HY-N1347R

Robinetin (Standard)	Inhibitor
Robinetin (Standard) is the analytical standard of Robinetin. This product is intended for research and analytical applications. Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation.

HY-174388

Antifungal agent 134	Inhibitor
Antifungal agent 134 (Compound B13) is an antifungal agent with EC₅₀s of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL for Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata, respectively. Antifungal agent 134 can disrupt the cell membrane and mitochondria of the hyphae, leading to significant ROS accumulation. Antifungal agent 134 also has significant herbicidal activities against field weeds, such as Amaranthus retroflexus L and Abutilon theophrasti Medicus. Antifungal agent 134 can be used for crop diseases and field weeds research.

HY-N14191

Malonylniphimycin	Inhibitor
Malonylniphimycin is a macrolide antibiotic found in Streptomyces str. hygroscopicus B-7. Malonylniphimycin is resistant to Gram-positive bacteria, fungi and yeasts.

HY-N1422R

Hecogenin (Standard)	Inhibitor
Hecogenin (Standard) is the analytical standard of Hecogenin. This product is intended for research and analytical applications. Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.

HY-N15444

Bullatenone	Inhibitor
Bullatenone is a volatile bioactive compound that can be found in Lophomyrtus bullata. It has insect - repellent, anti - ulcer, anti - UV, and antifungal activities. Bullatenone can inhibit the growth of fungi such as Candida albicans and Cladosporium resinae. Bullatenone can be used in the research of diseases such as inflammation and infections.

HY-N14803

Nanaomycin B	Inhibitor
Nanaomycin B is an antibiotic. Nanaomycin B has anti-Gram-positive bacteria, mycobacteria, mycoplasma and fungi activity.

HY-N19184

Cladobotric acid H	Inhibitor
Cladobotric acid H is a polyketide antifungal agent found in the mycoparasitic fungus Hypomyces pseudocorticicola FKA-73. Cladobotric acid H inhibits growth of azole-sensitive and azole-resistant Candida auris, Aspergillus fumigatus, Aspergillus udagawae, Aspergillus felis, and Aspergillus lentulus. Cladobotric acid H can be used for the research of aspergillosis, candidiasis.

HY-183176

Laurolinium acetate	Inhibitor
Laurolinium acetate is a cationic antimicrobial agent. Laurolinium acetate exerts activity against Gram-positive and Gram-negative bacteria, and fungi. Laurolinium acetate can be used for the research of microbial infection.

HY-N13908

Acremonol	Inhibitor
Acremonol has anti-Gram-positive bacteria and fungal activity.

HY-B1474S1

Alexidine-d₁₀	Inhibitor
Alexidine-d₁₀ is the deuterium labeled Alexidine (HY-B1474). Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.

HY-N14283

Ezomycin D2	Inhibitor
Ezomycin D2 is an antifungal antibiotic. Ezomycin D2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.

HY-Y0603R

3-Hydroxyacetophenone (Standard)	Inhibitor
3-Hydroxyacetophenone (Standard) is the analytical standard of 3-Hydroxyacetophenone (HY-Y0603). This product is intended for research and analytical applications. 3-Hydroxyacetophenone (m-Hydroxyacetophenone) is a hydroxy-substituted alkyl phenyl ketone and also a plant defensin in carnations. 3-Hydroxyacetophenone has antifusarium activity. In addition, 3-Hydroxyacetophenone can be used to synthesize Rivastigmine (HY-17368).