2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N9357
    Granilin
    		Inhibitor 99.60%
    Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide.
    Granilin
  • HY-N6738
    Bafilomycin B1
    		Inhibitor 98.10%
    Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets.
    Bafilomycin B1
  • HY-41407
    2,3-Dimethoxybenzaldehyde
    		99.98%
    2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) is a benzaldehyde analog, with high antifungal activity (MIC=2.5 mM) 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) could be used for the synthesis of berberine.
    2,3-Dimethoxybenzaldehyde
  • HY-120734
    Quinoxyfen
    		Inhibitor 98.0%
    Quinoxyfen (DE-795) is a powdery mildew fungicide.
    Quinoxyfen
  • HY-N7133
    Diphenylamine hydrochloride
    		99.92%
    Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent.
    Diphenylamine hydrochloride
  • HY-W019852
    Flutriafol
    		Inhibitor 98.02%
    Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
    Flutriafol
  • HY-B0293A
    Butoconazole
    		Inhibitor 98.90%
    Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis.
    Butoconazole
  • HY-108970
    Bafilomycin D
    		Inhibitor 99.30%
    Bafilomycin D is a specific inhibitor of vacuolar-type ATPase (V-ATPase). Bafilomycin D has antimicrobial, insecticidal, herbicidal and cytotoxic activity.
    Bafilomycin D
  • HY-A0133
    Chlorphenesin
    		Inhibitor 99.84%
    Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics.
    Chlorphenesin
  • HY-N0216S1
    Benzoic acid-13C6
    		Inhibitor 99.66%
    Benzoic acid-13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
    Benzoic acid-<sup>13</sup>C<sub>6</sub>
  • HY-14273R
    Isavuconazole (Standard)
    		Inhibitor
    Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
    Isavuconazole (Standard)
  • HY-W016806
    Sodium methylparaben, 99%
    		Inhibitor 99.32%
    Sodium methylparaben, 99% (Sodium methyl 4-hydroxybenzoate, 99%) is an antifungal agent.
    Sodium methylparaben, 99%
  • HY-125539
    Roridin E
    		Inhibitor 99.82%
    Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies.
    Roridin E
  • HY-122800
    Pivalophenone
    		Inhibitor
    Pivalophenone (2,2-Dimethylpropiophenone) is a dimethylated compound with antifungal properties. Pivalophenone (compound 13) inhibits E. floccosum C 114 with a MIC of 50 µg/mL.
    Pivalophenone
  • HY-17514R
    Itraconazole (Standard)
    		Inhibitor
    Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
    Itraconazole (Standard)
  • HY-113219R
    Hydroxyphenyllactic acid (Standard)
    		Inhibitor
    Hydroxyphenyllactic acid (Standard) is the analytical standard of Hydroxyphenyllactic acid. This product is intended for research and analytical applications. Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid (Standard)
  • HY-136436A
    Ternidazole
    		Inhibitor 99.11%
    Ternidazole is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole effectively alleviates chronic alcoholism. Ternidazole can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism.
    Ternidazole
  • HY-113430
    5-n-Heneicosylresorcinol
    		Inhibitor 98.0%
    5-n-Heneicosylresorcinol (5-Heneicosylresorcinol) is an active n-alkyl(enyl)resorcinols (AR) occurring in cereal products from Colombia. Antifungal activity.
    5-n-Heneicosylresorcinol
  • HY-Y1313
    3-Nitrobenzoic acid
    		Inhibitor 99.91%
    3-Nitrobenzoic acid (m-Carboxynitrobenzene; m-Nitrobenzenecarboxylic acid; m-Nitrobenzoic acid) is an antioxidant and antibacterial agent that can kill bacteria and fungi. 3-Nitrobenzoic acid can be degraded or reduced by certain bacteria (such as Pseudomonas) and fungi (such as white rot fungi) into aldehydes and alcohols.
    3-Nitrobenzoic acid
  • HY-119847
    Abafungin
    		Inhibitor 99.10%
    Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses.
    Abafungin
Cat. No. Product Name / Synonyms Application Reactivity