GPR139 Antagonist
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NCRW0005-F05
0 ImagesNCRW0005-F05 is a GPR139 antagonist with an IC50 of 147.9 nM against zebrafish GPR139. NCRW0005-F05 blocks agonist-induced GPR139 activity and inhibits intracellular calcium mobilization. NCRW0005-F05 suppresses fear memory consolidation, increases and decreases the peak amplitude of calcium transients, reduces KCl-induced calcium transients, induces thigmotaxis, and decreases locomotor speed after conditioning. NCRW0005-F05 can be used in research related to Parkinson's disease, diabetes, and obesity.
