Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Antagonist
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Glycosidase Activators
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Glycosidase Modulators
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Glycosidase Chemical
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Glycosidase Inducers
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Glycosidase Degrader
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Glycosidase Controls
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (697)
Related Products (697)
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Antibodies (3)
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Galactostatin
0 ImagesCat. No.: HY-N15004CAS No.: 107537-94-0Galactostatin is a β-galactosidase inhibitor.
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Lupinalbin A
0 ImagesCat. No.: HY-N4069CAS No.: 98094-87-2Synonyms: Boeravinone LLupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor with IC50 values of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity.
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Arisanschinin D
0 ImagesCat. No.: HY-N12790CAS No.: 1314021-69-6Synonyms: Ananonin BArisanschinin D (Ananonin B) is an α-Glucosidase inhibitor and can be isolated from Schisandra arisanensis Hay.
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Petunidin-3-O-glucoside chloride (Standard)
0 ImagesPetunidin-3-O-glucoside chloride (Standard) is the analytical standard of Petunidin-3-O-glucoside chloride (HY-N7832). This product is intended for research and analytical applications. Petunidin-3-O-glucoside chloride is a blood-brain barrier-penetrating tyrosinase inhibitor with an IC50 of 10.3 μM and a Ki of 9.0 μM. Petunidin-3-O-glucoside also acts as an α-glucosidase inhibitor with an IC50 of 218.2 µM. Petunidin-3-O-glucoside chloride inhibits the SIRT3/p53-mediated mitochondrial pathway and the PI3K/Akt-ERK pathway, suppresses glycolysis, and induces cell apoptosis. Petunidin-3-O-glucoside chloride scavenges ROS to exert antioxidant activity. It can be used in research related to glioblastoma multiforme, skin anti-aging and whitening, as well as obesity.
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OAT-1441
0 ImagesCat. No.: HY-180321CAS No.: 2088453-79-4OAT-1441 is a selective hAMCase inhibitor with oral activity (IC50 = 7 nM). OAT-1441 can be used to study the physiological functions of hAMC enzymes.
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Adiposin
0 ImagesCat. No.: HY-N14914CAS No.: 83764-11-8Adiposin, a microbial metabolite, is an α-glucoside hydrolase inhibitor.
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Hexylresorcinol (Standard)
0 ImagesHexylresorcinol (Standard) is the analytical standard of Hexylresorcinol. This product is intended for research and analytical applications. Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage.
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α-Amylase/α-Glucosidase-IN-14
0 ImagesCat. No.: HY-162635CAS No.: 3047450-65-4α-Amylase/α-Glucosidase-IN-14 (compound 6E) is an oral bioactive inhibitor of α-amylase and α-glucosidase, with the IC50s of 45.53 μM and 27.73 μM, respectively.
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β-1,3-1,4-Glucanase
0 ImagesCat. No.: HY-N8279CAS No.: 62213-14-3Synonyms: Endo-β-1,3-1,4-glucanaseβ-1,3-1,4-glucanase (Endo-β-1,3-1,4-glucanase) is a glycoside hydrolase family 16 enzyme (some members belong to subfamily 25). β-1,3-1,4-glucanase shows high substrate specificity toward mixed‑linked β‑glucans and cleaves β‑1,4 glycosidic bonds adjacent to β‑1,3 linkages in an endo‑type pattern. β-1,3-1,4-glucanase can be used in industrial enzyme applications and monogastric animal feed supplementation.
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Rebaudioside A (Standard)
0 ImagesCat. No.: HY-N0466RCAS No.: 58543-16-1Rebaudioside A (Standard) is the analytical standard of Rebaudioside A. This product is intended for research and analytical applications. Rebaudioside A is an orally effective steviol glycoside with high sweetness. Rebaudioside A acts as an inhibitor of α-glucosidase with an IC50 value of 35.01 μg/mL. Rebaudioside A increases the ATP/ADP ratio in β cells in a glucose-dependent manner, thereby inhibiting KATP channels, leading to membrane depolarization, calcium influx, and ultimately stimulating insulin secretion. Rebaudioside A activates the SREBP signaling pathway by inhibiting HMGCR, the rate-limiting enzyme in cholesterol synthesis, resulting in increased expression of LDLR on the cell surface, thus promoting the uptake of LDL-C in the blood. Rebaudioside A can be used for studies on blood glucose and lipid regulation as well as anti-obesity.
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Conduritol B epoxide (Standard)
0 ImagesConduritol B epoxide (Standard) is the analytical standard of Conduritol B epoxide (HY-100944). This product is intended for research and analytical applications. Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor.
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8-Demethoxyschinilenol
0 ImagesCat. No.: HY-N17127CAS No.: 144398-46-98-Demethoxyschinilenol is a terpenoid coumarin. 8-Demethoxyschinilenol can be isolated from the leaves of Zanthoxylum schinifolium. 8-Demethoxyschinilenol exhibits moderate inhibitory activity against α-glucosidase, with an IC50 of 164.4 μM.
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2-Methylcardol triene
0 ImagesCat. No.: HY-122522CAS No.: 50423-15-92-Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50=39.6 μM). 2-Methylcardol triene is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM. 2-Methylcardol triene has been used as a starting material for the synthesis of mono- and bis-benzoxazines.
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Maltose monohydrate-13C
0 ImagesCat. No.: HY-N2024AS2Maltose monohydrate-13C is the 13C labeled isotope of Maltose monohydrate. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.
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Castanospermine (Standard)
0 ImagesCastanospermine is a natural alkaloid that can be extracted from black beans or the Moreton Bay chestnut tree (Castanospermum australae). Castanospermine is an α/ β-glucosidase inhibitor. Castanospermine has anti-inflammatory, antiviral replication and anti-metastatic effects on prostate cancer. Castanospermine can be used as an immunosuppressant to prevent transplant rejection.
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α-Glucosidase-IN-117
0 ImagesCat. No.: HY-186199CAS No.: 2410538-77-9α-Glucosidase-IN-117 is a low-activity α-glucosidase (α-glucosidase) inhibitor belonging to the coumarin derivative class, with an inhibition rate of 19.51% at 100 μM. α-Glucosidase-IN-117 can be used in diabetes research.
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Cefetrizole
0 ImagesCat. No.: HY-U00266CAS No.: 65307-12-2Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively.
