HSP
Heat shock proteins
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.
HSP Isoform Specific Products
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HSP Inhibitors
(321)
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HSP Agonists
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HSP Antagonists
(5)
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HSP Activators
(84)
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HSP Modulators
(6)
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HSP Inducers
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HSP Degraders
(7)
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HSP Pre-designed Set
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HSP Controls
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HSP Ligands
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HSP Related Products (491)
Related Products (491)
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Antibodies (46)
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HSP Isoform Comparison
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CYP51/Hsp90-IN-1
0 ImagesCat. No.: HY-170816CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis.
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ML189
0 ImagesCat. No.: HY-127179CAS No.: 337328-21-9ML189 is an HSP90 inhibitor. ML189 can be used in the research of infectious diseases such as candidiasis.
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DCZ3112
0 ImagesCat. No.: HY-187653CAS No.: 2556837-25-1DCZ3112 is a Hsp90/Cdc37 protein-protein interaction inhibitor, with a Kd value of 4.98 µM against human Hsp90. DCZ3112 binds to the N-terminal domain of Hsp90, disrupts the Hsp90-Cdc37 interaction, and does not inhibit the ATPase activity of Hsp90. DCZ3112 induces G1 phase cell cycle arrest, apoptosis, reduces the phosphorylation levels of AKT and ERK, and inhibits the proliferation of HER2-positive breast cancer cells. DCZ3112 can be used in breast cancer-related research.
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SNX-2112 (Standard)
0 ImagesCat. No.: HY-10214RCAS No.: 908112-43-6Synonyms: PF-04928473 (Standard)SNX-2112 (Standard) is the analytical standard of SNX-2112 (HY-10214). This product is intended for research and analytical applications. SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 nM, 4.275 μM and 0.862 μM, respectively. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively.
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BIIB021 (Standard)
0 ImagesCat. No.: HY-10212RCAS No.: 848695-25-0Synonyms: CNF2024 (Standard)BIIB021 (Standard) is the analytical standard of BIIB021. This product is intended for research and analytical applications. BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively.
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KNK437 (Standard)
0 ImagesSynonyms: Heat Shock Protein Inhibitor I (Standard)
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Hsp90-Cdc37-IN-1 (Standard)
0 ImagesCat. No.: HY-111414RCAS No.: 2227303-22-0Hsp90-Cdc37-IN-1 (Standard) is the analytical standard of Hsp90-Cdc37-IN-1 (HY-111414). This product is intended for research and analytical applications. Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC50 of 140 nM.
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WK88-1
0 ImagesCat. No.: HY-164548CAS No.: 958888-32-9WK88-1 is an apoptosis inducer and Hsp90 client protein inhibitor with antiproliferative and immunomodulatory activities. WK88-1 inhibits signaling pathways such as PI3K/Akt and NF-κB, and induces mitochondrial dysfunction and cell cycle arrest. WK88-1 effectively suppresses cancer cell migration and invasion, and reverses various EGFR mutations and resistance to Gefitinib (HY-50895). WK88-1 also regulates the differentiation of monocytes and dendritic cells, blocks the expression of multiple chemokines, inhibits immune cell migration and M1 marker transcription, and restores impaired endocytic activity. WK88-1 has been used in studies of breast cancer, non-small cell lung cancer with various EGFR mutations or Met amplification, and atherosclerosis and other related diseases.
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Gamitrinib TPP hexafluorophosphate (Standard)
0 ImagesCat. No.: HY-102007ARCAS No.: 1131626-47-5Gamitrinib TPP hexafluorophosphate (Standard) is the analytical standard of Gamitrinib TPP hexafluorophosphate (HY-102007A). This product is intended for research and analytical applications. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
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Luminespib mesylate
0 ImagesCat. No.: HY-10215ACAS No.: 1051919-21-1Synonyms: VER-52296 mesylate; AUY922 mesylate; NVP-AUY922 mesylateLuminespib mesylate (VER-52296 mesylate) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively.
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Displurigen (Standard)
0 ImagesCat. No.: HY-111002RCAS No.: 96156-26-2Synonyms: NSC375009 (Standard)Displurigen (Standard) is the analytical standard of Displurigen (HY-111002). This product is intended for research and analytical applications. Displurigen (NSC375009) disrupts human embryonic stem cell pluripotency by targeting HSPA8. Displurigen inhibits ATPase activity of HSP70 (IC50 = 225 μM).
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O-Carboranylphenoxyacetanilide
0 ImagesCat. No.: HY-D2360CAS No.: 1220716-15-3
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PF-4942847
0 ImagesCat. No.: HY-108336CAS No.: 1046859-34-0PF-4942847 is an orally active HSP90 inhibitor with an IC50 of approximately 50 nM. PF-4942847 induces apoptosis in osteosarcoma cells, increases the proportion of cells in the sub-G1 phase and PARP cleavage, reduces the expression of Akt, Erk, MYC, c-MET and STAT-3, and regulates HSP expression. PF-4942847 can be used in studies related to osteosarcoma and HSP90.
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ML229
0 ImagesCat. No.: HY-127183CAS No.: 898918-58-6ML229 is an HSP90 inhibitor. ML229 can be used in the research of infectious diseases such as candidiasis.
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BIIB-028
0 ImagesCat. No.: HY-12933CAS No.: 911398-13-5BIIB-028 is an orally active inhibitor for heat shock protein 90 (Hsp90). BIIB-028 targets the ATP-binding site of Hsp90, disrupts the function of Hsp90, leads to the degradation of client proteins, that are crucial for cancer cell survival and proliferation.
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G3130
0 ImagesCat. No.: HY-111300CAS No.: 848952-37-4G3130 is a reversible HSP90 inhibitor with a Kd value of 280 nM for the N-terminal ATP-binding domain of purified human Hsp90α. G3130 binds to the adenine site via a multi-hydrogen bond network. G3130 induces the degradation of Hsp90 client protein Her-2 in breast cancer cells. G3130 activates Hsp70 promoter-driven luciferase expression in 293T cells. G3130 can be used in breast cancer-related research.
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JG-48
0 ImagesCat. No.: HY-116279CAS No.: 1627122-26-2JG-48 is a Hsp70 inhibitor that can reduce tau levels in models of tauopathy.
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Retaspimycin
0 ImagesCat. No.: HY-15263CAS No.: 857402-23-4
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VER-155008 (Standard)
0 ImagesCat. No.: HY-10941RCAS No.: 1134156-31-2VER-155008 (Standard) is the analytical standard of VER-155008 (HY-10941). This product is intended for research and analytical applications. VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
