HSP
Heat shock proteins (HSPs) are molecular chaperones that support proteostasis by preventing protein misfolding and aggregation during nascent-chain folding and cellular stress[1]. Mechanistically, HSP70 acts upstream on nascent and newly synthesized polypeptides, while HSP90 supports folding and maturation of selected client proteins through coordinated chaperone cycles[1][2]. In cancer models, HSP90 buffers oncogenic signaling proteins and enables malignant cells to tolerate imbalanced signaling, making HSP90 inhibition a practical strategy for disrupting multiple client pathways[3][4]. Compared with ATP-dependent HSP70/HSP90 systems, HSP27/HSPB1 is a small heat shock protein whose oligomer-monomer dynamics regulate chaperone activity and whose redox-sensitive monomers suppress aggregation in vitro[5]. HSP27 also regulates apoptosis by interacting with cytochrome c and blocking downstream apoptotic complex formation, supporting its use in cell-death and stress-response experiments[6]. For experimental applications, HSP90 inhibitors provide tools to test client-protein dependence, while HSP27-focused assays can examine aggregation control, redox stress, and apoptosis regulation[4][5][6].
References:
- [1]. Hartl FU, et al. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002 Mar 8;295(5561):1852-8. [Content Brief]
- [2]. Dahiya V, et al. The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones. Mol Cell. 2022 Apr 21;82(8):1543-1556.e6. [Content Brief]
- [3]. Whitesell L, et al. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005 Oct;5(10):761-72. [Content Brief]
- [4]. Neckers L, et al. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
- [5]. Alderson TR, et al. Local unfolding of the HSP27 monomer regulates chaperone activity. Nat Commun. 2019 Mar 6;10(1):1068. [Content Brief]
- [6]. Bruey JM, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000 Sep;2(9):645-52. [Content Brief]
All Product Categories
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HSP Related Products (236)
Related Products (236)
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Antibodies (7)
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Bimoclomol
0 ImagesBimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.
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PET-16
0 ImagesPET-16 is a selective HSP70 inhibitor that binds to an allosteric pocket of the substrate-binding domain. PET-16 inhibits the ability of HSP70 to cycle between ATP-bound and ADP-bound states. PET-16 induces apoptosis in multiple myeloma.
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Hsp90-Cdc37-IN-1
0 ImagesHsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC50 of 140 nM.
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CCT245232
0 ImagesCCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1).
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Tamoxifen-d3 hydrochloride
0 ImagesCat. No.: HY-13757SPurity: 98.99%Synonyms: ICI 46474-d3 hydrochloride; (Z)-Tamoxifen-d3 hydrochloride; trans-Tamoxifen-d3 hydrochlorideTamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.
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HVH-2930
0 ImagesCat. No.: HY-161781CAS No.: 3034605-72-3HVH-2930 is a HSP90 C-terminal domain inhibitor with high oral bioavailability. HVH-2930 downregulates HSP90 client proteins, inhibits the HER2 signaling pathway, induces apoptosis, and suppresses the proliferation of breast cancer cells. HVH-2930 inhibits the proliferation of tumors sensitive or resistant to Trastuzumab (HY-P9907). HVH-2930 is applicable to relevant research on breast cancer.
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Adezmapimod (Standard)
0 ImagesSynonyms: SB 203580 (Standard); RWJ 64809 (Standard)Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.
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Benzbromarone (Standard)
0 ImagesBenzbromarone (Standard) is the analytical standard of Benzbromarone. This product is intended for research and analytical applications. Benzbromarone is an orally active anti-gout agent. Benzbromarone has anti-infammatory, anti-oxidative stress and nephroprotective effects. Benzbromarone can be used for the research of hyperuricemia and gout.
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HSP70/DnaK substrate peptide TFA
0 ImagesCat. No.: HY-P10541APurity: 98.06%HSP70/DnaK substrate peptide TFA is a short peptide that the HSP70/DnaK molecular chaperone can bind and act on. HSP70/DnaK substrate peptide TFA can be used to study the mechanism of action of HSP70/DnaK in molecular chaperone function.
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4-Br-Bnlm
0 Images4-Br-Bnlm is a selective inhibitor of glucose-regulated protein 94 (Grp94) with an EC50 value of 0.96 µM. 4-Br-Bnlm reduces the levels of mutant myocilin proteins as well as wild-type myocilin misfold in cells. 4-Br-Bnlm promotes the clearance of toxic formsof myocilin and reduces myocilin toxicity.
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10,11-Dehydrocurvularin
0 Images10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.
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Hsp110-STAT3 PPI-IN-1
0 ImagesCat. No.: HY-Q43097CAS No.: 882582-26-5Row174336 (compound 29) is a potent inhibitor of Hsp110-STAT3 interaction that shows antiproliferative activity against HPAEC cell line, with the IC50 of 22.67 μM.
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Tamoxifen-d3
0 ImagesCat. No.: HY-13757AS1CAS No.: 508201-30-7Synonyms: ICI 47699-d3; (Z)-Tamoxifen-d3; trans-Tamoxifen-d3Tamoxifen-d3 is the deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse.
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Kongensin A
0 ImagesKongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.
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Tanespimycin (Standard)
0 ImagesSynonyms: 17-AAG (Standard); NSC 330507 (Standard); CP 127374 (Standard)Tanespimycin (Standard) is the analytical standard of Tanespimycin. This product is intended for research and analytical applications. Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.
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Palmitic acid-d9
0 ImagesPalmitic acid-d9 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
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HSP90-IN-27
0 ImagesCat. No.: HY-156779CAS No.: 525577-38-2HSP90-IN-27 (compound 19) is an HSP90 inhibitor.
