HSP
Heat shock proteins (HSPs) are molecular chaperones that support proteostasis by preventing protein misfolding and aggregation during nascent-chain folding and cellular stress[1]. Mechanistically, HSP70 acts upstream on nascent and newly synthesized polypeptides, while HSP90 supports folding and maturation of selected client proteins through coordinated chaperone cycles[1][2]. In cancer models, HSP90 buffers oncogenic signaling proteins and enables malignant cells to tolerate imbalanced signaling, making HSP90 inhibition a practical strategy for disrupting multiple client pathways[3][4]. Compared with ATP-dependent HSP70/HSP90 systems, HSP27/HSPB1 is a small heat shock protein whose oligomer-monomer dynamics regulate chaperone activity and whose redox-sensitive monomers suppress aggregation in vitro[5]. HSP27 also regulates apoptosis by interacting with cytochrome c and blocking downstream apoptotic complex formation, supporting its use in cell-death and stress-response experiments[6]. For experimental applications, HSP90 inhibitors provide tools to test client-protein dependence, while HSP27-focused assays can examine aggregation control, redox stress, and apoptosis regulation[4][5][6].
References:
- [1]. Hartl FU, et al. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002 Mar 8;295(5561):1852-8. [Content Brief]
- [2]. Dahiya V, et al. The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones. Mol Cell. 2022 Apr 21;82(8):1543-1556.e6. [Content Brief]
- [3]. Whitesell L, et al. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005 Oct;5(10):761-72. [Content Brief]
- [4]. Neckers L, et al. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
- [5]. Alderson TR, et al. Local unfolding of the HSP27 monomer regulates chaperone activity. Nat Commun. 2019 Mar 6;10(1):1068. [Content Brief]
- [6]. Bruey JM, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000 Sep;2(9):645-52. [Content Brief]
All Product Categories
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HSP Related Products (236)
Related Products (236)
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Antibodies (7)
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Hsp90-IN-37
0 ImagesCat. No.: HY-W107935CAS No.: 1383133-23-0Hsp90-IN-37 (Z-2) is a heat shock protein 90 (Hsp90) inhibitor that inhibits Hsp90 enzymatic activity by 69%. Hsp90-IN-37 has antitumor activity.
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DiaPep277
0 ImagesDiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes.
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TRAP1-IN-1
0 ImagesCat. No.: HY-155063CAS No.: 3031102-94-7TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism.
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MK2-IN-5 acetate
0 ImagesCat. No.: HY-P10072APurity: 99.64%Synonyms: Hsp25 kinase inhibitor acetate; Mk2 pseudosubstrate acetateMK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation.
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Falcarinol
0 ImagesSynonyms: Panaxynol; CarotatoxinFalcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis. Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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PU-H54
0 ImagesPU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy. PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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SMTIN-T140
0 ImagesSMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells.
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BiP substrate
0 ImagesBiP substrate is a peptide substrate of BiP that can be used to measure the BiP ATPase activity.
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MK2-IN-1
0 ImagesMK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein.
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Paeoniflorin (Standard)
0 ImagesSynonyms: Peoniflorin (Standard)Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.
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Shepherdin (79-87) TFA
0 ImagesCat. No.: HY-P1750APurity: 99.80%Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.
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Sodium lactate ringer's solution
0 ImagesCat. No.: HY-158976Synonyms: Lactated ringer's solution (LRS)Sodium lactate ringer's solution (Lactated ringer's solution (LRS)) is an isotonic crystal intravenous injection and arthroscopic irrigation solution containing racemic sodium lactate and electrolytes such as sodium, potassium, calcium and chloride (130 mEq sodium/L, 274 mOsm/L), which can be used as a cell integrity protectant. Sodium lactate ringer's solution maintains the integrity of human meniscus cells, ensures that they retain normal cell morphology, membrane regularity, size and density, and does not alter the mRNA expression levels of α1 (I) procollagen, α1 (II) procollagen, aggrecan or HSP70. Sodium lactate ringer's solution can be applied to studies related to extracellular fluid deficiency and meniscus tears.
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Palmitic acid-d
0 ImagesPalmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
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Palmitic acid-d4-1
0 ImagesPalmitic acid-d4-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
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Hsp110/sGC-modulator-1
0 ImagesHsp110/sGC-modulator-1 (compound 17i), an orally active Hsp110/sGC dual-target regulator, exhibits optimal Hsp110 and sGC molecular activities as well as remarkable cell malignant phenotypes inhibitory and vasodilatory effects. Hsp110/sGC-modulator-1 (compound 17i) attenuates pulmonary vascular remodeling and right ventricular hypertrophy via Hsp110 suppression.
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HSP90-IN-22
0 ImagesHSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.
